Heritability of glaucoma and glaucoma-related endophenotypes: systematic review and meta-analysis protocol

BMJ Open
Nigus Gebrmedhin AsefaHarold Snieder

Abstract

Glaucoma is the second leading cause of age-related vision loss worldwide; it is an umbrella term that is used to describe a set of complex ocular disorders with a multifactorial aetiology. Both genetic and lifestyle risk factors for glaucoma are well established. Thus far, however, systematic reviews on the heritability of glaucoma have focused on the heritability of primary open-angle glaucoma only. No systematic review has comprehensively reviewed or meta-analysed the heritability of other types of glaucoma, including glaucoma-related endophenotypes. The aim of this study will be to identify relevant scientific literature regarding the heritability of both glaucoma and related endophenotypes and summarise the evidence by performing a systematic review and meta-analysis. This systematic review will follow the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols 2015 checklist, which provides a standardised approach for carrying out systematic reviews. To capture as much literature as possible, a comprehensive step-by-step systematic search will be undertaken in MEDLINE (PubMed), EMBASE, Web of Science and ScienceDirect, and studies published until 31 December 2017 will be included. Two reviewers will in...Continue Reading

References

Dec 1, 1970·Archives of Ophthalmology·R Z LeveneK Hirschhorn
Jan 1, 1994·Archives of Ophthalmology·J M TielschJ C Javitt
Dec 31, 1998·Archives of Ophthalmology·R C WolfsP T de Jong
Aug 27, 1999·Acta Ophthalmologica Scandinavica·M S GottfredsdottirE Stefánsson
Feb 17, 2000·Archives of Ophthalmology·L M WeihH R Taylor
Jul 12, 2001·Clinical & Experimental Ophthalmology·E RochtchinaR G Cumming
Jan 30, 2002·The British Journal of Ophthalmology·Paul J FosterGordon J Johnson
Nov 5, 2002·Nature Reviews. Genetics·Dorret BoomsmaLeena Peltonen
Apr 2, 2003·The American Journal of Psychiatry·Irving I Gottesman, Todd D Gould
Dec 24, 2003·Investigative Ophthalmology & Visual Science·Barbara E K KleinKristine E Lee
Apr 2, 2005·Nature Reviews. Genetics·David J Hunter
Nov 24, 2005·Eye·A Foster, S Resnikoff
Sep 19, 2006·Psychological Medicine·Jonathan Flint, Marcus R Munafò
Jan 11, 2007·Archives of Ophthalmology·Janey L Wiggs
Jul 27, 2007·Investigative Ophthalmology & Visual Science·Leonieke M E van KoolwijkHans G Lemij
Mar 6, 2008·Nature Reviews. Genetics·Peter M VisscherNaomi R Wray
Oct 22, 2008·International Ophthalmology Clinics·Pratap Challa
Dec 3, 2008·Mutation Research·S C SaccaA Izzotti
Sep 3, 2010·The Journal of Clinical Investigation·Bao Jian Fan, Janey L Wiggs
Sep 21, 2010·Survey of Ophthalmology·Paul G SanfilippoDavid A Mackey
Dec 22, 2010·Indian Journal of Ophthalmology·Douglas R Anderson
May 13, 2011·Eye·J H Fingert
Dec 3, 2011·The British Journal of Ophthalmology·Donatella Pascolini, Silvio Paolo Mariotti
Feb 24, 2012·Clinical & Experimental Ophthalmology·Robert J CassonIvan Goldberg
Jan 19, 2013·Nature Reviews. Genetics·Albert Tenesa, Chris S Haley
Jul 24, 2013·Trends in Molecular Medicine·Robert R H Anholt, Mary Anna Carbone
Sep 24, 2013·Progress in Retinal and Eye Research·Sarah F JanssenArthur A B Bergen
Dec 18, 2013·Investigative Ophthalmology & Visual Science·Ronald Klein, Barbara E K Klein
May 16, 2014·JAMA : the Journal of the American Medical Association·Robert N WeinrebFelipe A Medeiros
Jun 17, 2014·Fertility and Sterility·Mohamad Irani, Zaher Merhi
Jan 4, 2015·BMJ : British Medical Journal·Larissa ShamseerUNKNOWN PRISMA-P Group
Apr 14, 2015·BioMed Research International·Varsha P BrahmkhatriHanudatta S Atreya
May 20, 2015·Nature Genetics·Tinca J C PoldermanDanielle Posthuma
Aug 20, 2015·The British Journal of Ophthalmology·Venediktos V KapetanakisAlicja R Rudnicka
Oct 29, 2015·Maturitas·Madeleine Zetterberg
Sep 1, 2014·Journal of Current Glaucoma Practice·Sharmila RajendrababuS R Krishnadas
Jul 29, 2016·JAMA Ophthalmology·Phillippa M CumberlandUNKNOWN UK Biobank Eye and Vision Consortium
Nov 30, 2016·Current Opinion in Ophthalmology·Matthew A MillerDaniel I Bettis

❮ Previous
Next ❯

Citations

Mar 19, 2019·Current Opinion in Ophthalmology·Sayoko E MoroiJulia E Richards
Mar 10, 2019·Molecular Genetics & Genomic Medicine·Ling Zhang, Bin Chen

❮ Previous
Next ❯

Software Mentioned

RefWorks
Google Scholar
PRISMA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.