Heritability of hemodynamic reactivity to laboratory stressors in a homogenous Arab population: 'Oman Family Study'

Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies
Mohammed O HassanSulayma Albarwani

Abstract

Exaggerated cardiovascular reactivity to stressful stimuli may be a risk factor for the development of hypertension. The genetic influence on blood pressure (BP) reactivity to stress and its control mechanisms has been receiving considerable support. This study aims at examining the heritability of BP and its intermediate hemodynamic phenotypes to acute stress in a homogeneous Arab population. Parameters were computed from continuous BP, electrocardiography and impedance cardiography measurements, during rest, word conflict (WCT) and cold pressor (CPT) tests. Heritability estimates (h(2)) were obtained using the variance components-based approach implemented in the SOLAR software package. Reactivity scores for WCT and CPT increased significantly (P < .05) for systolic (SBP), diastolic (DBP), heart rate (HR), cardiac output (CO), and total peripheral resistance (TPR). They decreased significantly (P < .05) for stroke volume (SV), left ventricular ejection time (LVET), end diastolic (EDI) and cardiac contractility (IC) indices. Univariate analysis detected heritability estimates that ranged from 0.19-0.35 for rest, 0.002-0.40 for WCT and 0.08-0.35 for CPT. In this unique cohort, resting as well as challenged cardiovascular phenot...Continue Reading

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Citations

Sep 13, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Sulayma AlbarwaniMohammed O Hassan
Jun 1, 2011·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Mohammed O HassanAnthony G Comuzzie
Mar 7, 2015·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Biqi WangLiming Li

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