Heritability of Hippocampal Formation Sub-region Volumes

Journal of Neurology and Neuroscience
Kiefer S GreenspanTheo G M Van Erp

Abstract

Hippocampal formation (HF) volume and episodic memory performance are substantially heritable, but HF subregion heritability estimates and their possible shared genetic variance with episodic memory performance remain to be determined. This study provides heritability estimates for hippocampal subregions (e.g, Cornu Amonis, Subiculum, Parasubiculum, Molecular and Granule Cell Layers of the Dentate Gryus) and Total HF volumes obtained using FreeSurfer 6.0. In addition, this study assesses the heritability of object sequence and verbal episodic memory performance, and the amount of shared genetic variance between HF subregions and Total HF volume and episodic memory performance. HF volumes were obtained from high-resolution brain scans from a sample of 499 siblings (mean age±SD=30.0±3.1, 203 men), including 51 monozygotic and 46 dizygotic twin pairs and 305 non-twin siblings, collected by the Human Connectome Project (www.humanconnectome.org). Heritability estimates for HF subregions ranged from 0.42-0.87 and shared genetic variance of HF subregions with hippocampal volume was substantial (mean=0.79, range=0.50-0.98). HF subregion volumes residualized for Total HF and percent HF subregion volumes were also found to be substantial...Continue Reading

Citations

Jan 13, 2018·International Journal of Molecular Sciences·Ayla Arslan
Jun 4, 2019·Psychological Medicine·Soichiro NakaharaTheo G M van Erp
Feb 22, 2021·Experimental Brain Research·Peka ChristovaApostolos P Georgopoulos
Jun 15, 2021·Neurology. Genetics·Natalia Vilor-TejedorGrégory Operto

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