Heritability of insulin secretion and insulin action in women with polycystic ovary syndrome and their first degree relatives

The Journal of Clinical Endocrinology and Metabolism
S ColillaD A Ehrmann

Abstract

Polycystic ovary syndrome (PCOS), one of the most common endocrine disorders of reproductive age women, is associated with an increased risk of type 2 diabetes mellitus. Defects in both insulin action and insulin secretion contribute to this predisposition to diabetes, but the extent to which these defects are heritable among PCOS families has not been examined. In the present study we used the frequently sampled iv glucose tolerance test to quantitate insulin secretion (AIRg), insulin action (Si), and their product (AIRg x Si) among women with PCOS (n = 33) and their nondiabetic first degree relatives (n = 48). We then quantitated the heritability of these measures from familial correlations estimated within a genetic model. Familial (spousal, rhoMF; parent-offspring, rhoPO; and sibling, rhoSS) correlations were derived for log-transformed body mass index (BMI) as well as for AIRg, Si, and AIRg x Si, the latter three of which were adjusted for BMI. There was no evidence of significant heritability for either lnBMI or lnSi in these families. In contrast, the sibling correlation (rhoSS = 0.74) for lnAIRg was highly significant (chi(2) = 7.65; 1 df; P = 0.006). In addition, the parameter quantitating insulin secretion in relation...Continue Reading

References

Jul 16, 1992·The New England Journal of Medicine·D A EhrmannZ Sheikh
Jan 1, 1988·Annual Review of Nutrition·C Bouchard, L Pérusse
Sep 1, 1987·The Journal of Clinical Endocrinology and Metabolism·A DunaifA Dobrjansky
Apr 13, 1999·The Journal of Clinical Endocrinology and Metabolism·S C ElbeinS E Kahn

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Citations

Feb 12, 2009·Journal of Assisted Reproduction and Genetics·Ashraf Moini, Bita Eslami
May 7, 2010·The Journal of Clinical Endocrinology and Metabolism·C M AckermanUNKNOWN HAPO Study Cooperative Research Group
Dec 2, 2009·Reproductive Biology and Endocrinology : RB&E·Yuping XuYunxia Cao
Jun 25, 2013·Journal of Assisted Reproduction and Genetics·Bhaskar Venkata Kameswara Subrahmanya LakkakulaUsha Rani Godla
Aug 30, 2008·The Medical Clinics of North America·Maryse BrassardJean-Patrice Baillargeon
Jul 8, 2008·Pharmacology & Therapeutics·H E WesterveldG M Dallinga-Thie
Dec 15, 2007·Metabolism: Clinical and Experimental·Susan SamAndrea Dunaif
Jun 15, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·Mark O Goodarzi, Ricardo Azziz
Jun 15, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·Julia Warren-Ulanch, Silva Arslanian
Dec 13, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Manuel Luque-RamírezHéctor F Escobar-Morreale

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