Heritability of measures of kidney disease among Zuni Indians: the Zuni Kidney Project.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Jean W MacCluerPhilip G Zager

Abstract

The long-term goal of the GKDZI (Genetics of Kidney Disease in Zuni Indians) Study is to identify genes, environmental factors, and genetic-environmental interactions that modulate susceptibility to renal disease and intermediate phenotypes. A community-based participatory research approach was used to recruit family members of individuals with kidney disease. The study was conducted in the Zuni Indians, a small endogamous tribe located in rural New Mexico. We recruited members of extended families, ascertained through a proband with kidney disease and at least 1 sibling with kidney disease. 821 participants were recruited, comprising 7,702 relative pairs. PREDICTOR OUTCOMES & MEASUREMENTS: Urine albumin-creatinine ratio (UACR) and hematuria were determined in 3 urine samples and expressed as a true ratio. Glomerular filtration rate (GFR) was estimated using the Modification of Diet in Renal Disease (MDRD) Study equation modified for American Indians. Probands were considered to have kidney disease if UACR was >or=0.2 in 2 or more of 3 spot urine samples or estimated GFR was decreased according to the CRIC (Chronic Renal Insufficiency Cohort) Study criteria. Kidney disease was identified in 192 participants (23.4%). There were ...Continue Reading

Associated Clinical Trials

Sep 26, 2016·Vallabh O ShahVallabh O Shah

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