Heritability of obsessive-compulsive trait dimensions in youth from the general population

Translational Psychiatry
Christie L BurtonPaul D Arnold

Abstract

Obsessive-compulsive disorder (OCD) is a heritable childhood-onset psychiatric disorder that may represent the extreme of obsessive-compulsive (OC) traits that are widespread in the general population. We report the heritability of the Toronto Obsessive-Compulsive Scale (TOCS), a new measure designed to assess the complete range of OC traits in youth. We also examined the dimensional nature of the TOCS and the degree to which genetic effects are unique or shared between dimensions. OC traits were measured using the TOCS in 16,718 youth (6-18 years) at a science museum. We conducted a factor analysis to identify OC trait dimensions. We used univariate and multivariate twin models to estimate the heritability of OC trait dimensions in a subset of twins (220 pairs). Six OC dimensions were identified: Cleaning/Contamination, Symmetry/Ordering, Rumination, Superstition, Counting/Checking, and Hoarding. The TOCS total score (74%) and each OC dimension was heritable (30-77%). Hoarding was not highly correlated with other OC dimensions, but did share genetic effects. Shared genetics accounted for most of the shared variance among dimensions, whereas unique environment accounted for the majority of dimension-specific variance. One excep...Continue Reading

References

Nov 1, 1975·Archives of General Psychiatry·D J CohenW Pollin
May 1, 1987·Archives of General Psychiatry·K S KendlerL J Eaves
Nov 1, 1983·Psychological Medicine·T R InselD L Murphy
Apr 18, 2000·Archives of General Psychiatry·G NestadtR Hoehn-Saric
Dec 20, 2000·American Journal of Medical Genetics·A H JonnalK S Kendler
Jan 7, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Gregory L HannaBrenda W Gillespie
Oct 7, 2005·Behaviour Research and Therapy·Tord Ivarsson, Robert Valderhaug
Nov 23, 2005·Behaviour Research and Therapy·Dean McKayJillian Miller
Jan 21, 2006·Journal of Child Psychology and Psychiatry, and Allied Disciplines·James J HudziakRichard D Todd
Sep 5, 2006·Biological Psychiatry·Daniël S van GrootheestDorret I Boomsma
Sep 27, 2006·Psychological Medicine·Derek BoltonThalia C Eley
Dec 13, 2006·Biological Psychiatry·S Evelyn StewartDavid L Pauls
Feb 10, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Carol A MathewsNicholas J Schork
Jun 27, 2007·Psychological Medicine·Daniël S Van GrootheestDorret I Boomsma
Dec 18, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Daniël S van GrootheestKenneth S Kendler
Mar 18, 2008·Journal of the American Academy of Child and Adolescent Psychiatry·David Mataix-ColsIsobel Heyman
Jun 4, 2008·Journal of the American Academy of Child and Adolescent Psychiatry·S Evelyn StewartDavid L Pauls
Aug 14, 2008·Journal of the American Academy of Child and Adolescent Psychiatry·Daniël S van GrootheestDorret I Boomsma
Oct 17, 2008·The American Journal of Psychiatry·Michael H BlochJames F Leckman
Oct 28, 2009·Nature Reviews. Genetics·Robert PlominOliver S P Davis
Apr 3, 2010·Behavior Genetics·Hilga KaterbergDanielle C Cath
Apr 9, 2010·Journal of Abnormal Child Psychology·Janette MooreFrancis A O'Neill
Jun 8, 2011·Archives of General Psychiatry·Alessandra C IervolinoDavid Mataix-Cols
May 23, 2012·Molecular Psychiatry·S van der SluisC V Dolan
Apr 1, 2011·Psychometrika·Steven BokerJohn Fox
Mar 5, 2013·Lancet·UNKNOWN Cross-Disorder Group of the Psychiatric Genomics Consortium
May 21, 2014·Nature Reviews. Neuroscience·David L PaulsDaniel A Geller
Jul 30, 2014·Psychological Medicine·C A MathewsD I Boomsma
Mar 27, 2016·Journal of the American Academy of Child and Adolescent Psychiatry·Laura S ParkPaul D Arnold
Aug 2, 2017·Molecular Psychiatry·UNKNOWN International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and OCD Collaborative Genetics Asso

❮ Previous
Next ❯

Citations

Jul 20, 2019·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Vanessa M SinopoliPaul D Arnold
Sep 3, 2020·Scientific Reports·Jeggan TiegoMurat Yücel
Jan 5, 2021·Frontiers in Human Neuroscience·Camila Bonin PintoA Vania Apkarian
May 8, 2021·Frontiers in Psychiatry·Srinivas BalachanderBiju Viswanath
May 26, 2021·Psychological Medicine·Behrang MahjaniChristie Burton
Jul 20, 2021·Autism Research : Official Journal of the International Society for Autism Research·Aline LefebvreRichard Delorme
Jul 23, 2021·Translational Psychiatry·Nora I StromLea K Davis

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

SPSS Statistics
ACE
SAS
OpenMx

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Related Papers

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Daniël S van GrootheestKenneth S Kendler
© 2022 Meta ULC. All rights reserved