Abstract
Oral microbes that colonize in the mouths of humans contribute to disease susceptibility, but it is unclear if host genetic factors mediate colonization. We therefore tested the hypothesis that the levels at which oral microbes colonize in the mouth are heritable. Dental plaque biofilms were sampled from intact tooth surfaces of 118 caries-free twins. An additional 86 caries-active twins were sampled for plaque from carious lesions and intact tooth surfaces. Using a reverse capture checkerboard assay the relative abundance of 82 bacterial species was determined. An integrative computational predictive model determined microbial abundance patterns of microbial species in caries-free twins as compared to caries-active twins. Heritability estimates were calculated for the relative microbial abundance levels of the microbial species in both groups. The levels of 10 species were significantly different in healthy individuals than in caries-active individuals, including, A. defectiva, S. parasanguinis, S. mitis/oralis, S. sanguinis, S. cristatus, S. salivarius, Streptococcus sp. clone CH016, G. morbillorum and G. haemolysans. Moderate to high heritability estimates were found for these species (h(2) = 56%-80%, p < .0001). Similarity ...Continue Reading
References
Dec 1, 1984·Infection and Immunity·W J LoescheB Burt
Feb 1, 1996·Journal of Dental Research·L M KasteL J Brown
Dec 17, 1997·Nature Genetics·N MartinG Machin
May 23, 1998·American Journal of Human Genetics·L Almasy, J Blangero
Jun 27, 1998·Caries Research·N SuzukiY Kurihara
Nov 24, 1999·Human Immunology·R T ActonP W Caufield
Feb 7, 2001·Journal of Medical Genetics·Y ZhangT C Hart
May 24, 2001·Journal of Bacteriology·B J PasterF E Dewhirst
Dec 12, 2001·Oral Microbiology and Immunology·Y OzawaS Sakamoto
Mar 7, 2002·Journal of Clinical Microbiology·Mitzi R BeckerAnn L Griffen
Nov 5, 2002·Nature Reviews. Genetics·Dorret BoomsmaLeena Peltonen
Feb 14, 2003·Lancet·Francisco Guarner, Juan-R Malagelada
Jun 17, 2003·Journal of Medical Microbiology·Susanna PajuFrank A Scannapieco
Dec 3, 2003·Australian Dental Journal·G C TownsendW Schwerdt
Mar 12, 2004·Clinical and Diagnostic Laboratory Immunology·Mohammad Abdus SalamHidenobu Senpuku
Jul 10, 2004·Journal of Clinical Microbiology·M A MunsonW G Wade
Feb 11, 2005·The Pediatric Infectious Disease Journal·Fabrizio GimiglianoLuigi Ballerini
Feb 22, 2005·Oral Microbiology and Immunology·M L L WallengrenJ Nordberg
Mar 3, 2005·Archives of Oral Biology·P M A CorbyM Vanyukov
Apr 28, 2005·Periodontology 2000·Sigmund S Socransky, Anne D Haffajee
May 26, 2005·Caries Research·W A BretzN J Schork
Nov 8, 2005·Journal of Clinical Microbiology·Jørn A AasFloyd E Dewhirst
Nov 8, 2005·Journal of Clinical Microbiology·P M CorbyB J Paster
Dec 6, 2005·Applied Bioinformatics·Satish Patel, James Lyons-Weiler
Dec 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Matthew A Zapala, Nicholas J Schork
Citations
Mar 3, 2009·Genome Research·Ivan NasidzeMark Stoneking
Oct 16, 2012·Genome Research·Simone S StahringerKenneth S Krauter
Jul 27, 2010·Journal of Bacteriology·Floyd E DewhirstWilliam G Wade
Sep 10, 2010·Journal of Clinical Microbiology·Erin L GrossAnn L Griffen
Sep 13, 2013·BMC Microbiology·Jing LiMark Stoneking
Mar 5, 2011·BMC Medical Genomics·Wim CrielaardBart J F Keijser
Oct 24, 2012·PloS One·Erin L GrossAnn L Griffen
Mar 23, 2013·PloS One·Scott N PetersonWalter Bretz
Apr 18, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Walter A BretzNicholas J Schork
Aug 27, 2010·International Journal of Oral Science·Li-na LiWen-yuan Shi
Jan 24, 2014·Microbiome·Anna EdlundJeffrey S McLean
Feb 8, 2014·Microbial Ecology·Wen JiangHui Chen
Apr 15, 2011·Journal of Clinical Periodontology·Anastasia PapapostolouPurnima S Kumar
Dec 8, 2010·Periodontology 2000·Jørgen Slots, Henrik Slots
Feb 28, 2015·Australian Dental Journal·S OpalI Walia
Oct 27, 2011·International Journal of Dentistry·Michelle R BockmannGrant C Townsend
Nov 3, 2015·PloS One·Meng ZhangMinquan Du
Apr 19, 2016·Oral Diseases·Hyo-Seol LeeJae-Ho Lee
Sep 16, 2016·Microbial Ecology·Andres Gomez, Karen E Nelson
Jul 4, 2018·Oral Diseases·Kausar Sadia FakhruddinLakshman Perera Samaranayake
Dec 19, 2018·Oral Diseases·Sergey V CherkasovAndrey O Plotnikov
Feb 28, 2019·Clinical Oral Investigations·Mônica Gentil MattosAline de Almeida Neves
Aug 25, 2017·BMC Genomics·Brittany A DemmittKenneth S Krauter
Sep 10, 2020·Scientific Reports·Thyagaseely S PremarajYanjiao Zhou
May 16, 2020·Scientific Reports·Marcelo FreireKaren E Nelson
Jan 12, 2018·AIMS Microbiology·Neetu SharmaNavneet Batra
Apr 21, 2020·Probiotics and Antimicrobial Proteins·Bhagavathi Sundaram SivamaruthiChaiyavat Chaiyasut
Jan 16, 2021·Journal of Dentistry·Armelia Sari WidyarmanChaminda Jayampath Seneviratne
Nov 18, 2020·BMC Oral Health·Matilda Handsley-DavisLaura S Weyrich
Mar 11, 2021·Periodontology 2000·A M Marije KaanEgija Zaura
Jun 4, 2019·Annals of Epidemiology·Audrey RensonJennifer B Dowd