Heritability of plasma concentrations of activated protein C in a Spanish population

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
José M SoriaFrancisco España

Abstract

The protein C anticoagulant pathway plays a crucial role in the regulation of fibrin formation. Protein C is activated on the surface of endothelial cells by the thrombin-thrombomodulin complex with the stimulation of the endothelial protein C receptor. The levels of circulating activated protein C reflect in-vivo protein C activation, and a low level of activated protein C is a risk factor for venous thromboembolism. The objective of the study was to assess the relative contributions of genetic and environmental factors to the variation in the levels of activated protein C and protein C. Blood samples were collected from 126 individuals belonging to 19 Spanish families, and heritability and common household effect were estimated for protein C, activated protein C and its complexes with protein C and alpha1-antitrypsin. In addition, we calculated the genetic correlation between protein C and activated protein C phenotypes. Although all phenotypes showed significant heritability, activated protein C phenotype resulted in a very high heritability of 83%, which clearly shows that this phenotype is strongly influenced by the action of gene(s). Furthermore, the bivariant analyses of protein C and activated protein C phenotypes indic...Continue Reading

References

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Sep 13, 2007·Thrombosis and Haemostasis·Pilar MedinaFrancisco España

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Citations

Mar 23, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Silvia NavarroFrancisco España
Aug 13, 2020·International Journal of Molecular Sciences·Laura MartosPilar Medina

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