Heritability of plasma leptin in a population sample of African-American families

Genetic Epidemiology
C RotimiR S Cooper

Abstract

The aim of this study was to examine familial patterns of plasma leptin levels and the potential association with cardiovascular risk factors in a population sample of African-American families recruited from metropolitan Chicago. The study included 68 mothers, 31 fathers, 143 daughters, and 119 sons, for a total of 361 individuals from 118 families. Leptin levels were adjusted for the effect of age separately for mothers, fathers, daughters, and sons. Residuals were then standardized before estimating familial correlation using the maximum-likelihood method available in SEGPATH. With the exception of height, plasma leptin level was strongly correlated with all measured anthropometric variables. Familial effect (i.e., heritability) of leptin levels was estimated as 39% in this population at high risk for over weight. A significant sex difference was observed, and most of the estimated familial effect may be attributed to genetic influences since the spouse correlation was not statistically different from zero. A strong nonshared environmental effect is also suggested, however.

References

Jul 4, 1986·JAMA : the Journal of the American Medical Association·A J StunkardZ Hrubec
Sep 1, 1995·Nature Medicine·F LönnqvistM Schalling
Jul 28, 1995·Science·M A PelleymounterF Collins
Feb 1, 1996·The New England Journal of Medicine·R V ConsidineT L Bauer
Dec 29, 1995·Cell·L A TartagliaR I Tepper
Feb 27, 1996·Biochemical and Biophysical Research Communications·R B LynnJ F Caro
Aug 1, 1996·Journal of Clinical Epidemiology·S L AtamanR Wilks
Dec 5, 1996·Nature·C O'Brien

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Citations

Feb 13, 2009·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Jeremy B JowettJohn Blangero
May 29, 2009·Clinical Endocrinology·Jiankang LiuHerman A Taylor
Jan 15, 2002·Genetic Epidemiology·Lisa J MartinAnthony G Comuzzie
Jul 10, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A LukeR S Cooper
Apr 1, 1999·Journal of Hypertension·K NarkiewiczV K Somers
Mar 13, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·W L LoweR S Cooper
Oct 24, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J H LeeR A Price
Jun 13, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K WalderE Ravussin
Oct 29, 2005·American Journal of Human Biology : the Official Journal of the Human Biology Council·Mika TanakaRyutaro Ohtsuka
Apr 5, 2002·Biological Research for Nursing·J S HarrellS Deng

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