Heritability of polycystic ovary syndrome in a Dutch twin-family study

The Journal of Clinical Endocrinology and Metabolism
J M VinkD I Boomsma


Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. There is evidence for a genetic component in PCOS based on familial clustering of cases. In the present study, the heritability of PCOS was estimated. Data from 1332 monozygotic twins (genetically identical) and 1873 dizygotic twins/singleton sisters of twins (who share on average 50% of their segregating genes) registered with The Netherlands Twin Register were used. PCOS was defined as less than nine menstrual cycles and acne or hirsutism in agreement with the 2003 Rotterdam consensus. Results point to a strong contribution of familial factors to PCOS. The resemblance in monozygotic twin sisters (tetrachoric correlation 0.71) for PCOS was about twice as large as in dizygotic twin and other sisters (tetrachoric correlation 0.38). Univariate analyses point to strong contributions of genetic factors to the variance in PCOS. Next, a trivariate genetic analysis of oligomenorrhea, acne, and hirsutism was carried out. This analysis confirmed that the familial component in PCOS is due to genetic factors. This study demonstrated a large influence of genetic factors to the pathogenesis of PCOS, justifying the search for susce...Continue Reading


Apr 25, 2012·Journal of Assisted Reproduction and Genetics·Junli HeXuliang Li
Oct 22, 2009·Endocrine·Jing WangYunxia Cao
May 7, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S Franks
Jan 26, 2011·Nature Reviews. Endocrinology·Mark O GoodarziRicardo Azziz
Jun 29, 2011·Seminars in Reproductive Medicine·Vasantha Padmanabhan, Almudena Veiga-Lopez
Jul 16, 2013·Genetic Testing and Molecular Biomarkers·Wenjing ShenMin Song
Sep 2, 2008·Human Reproduction·M O GoodarziR Azziz
Oct 16, 2008·Human Reproduction·Marlies E KevenaarJenny A Visser
Mar 13, 2009·Human Reproduction·Roy Homburg
Sep 8, 2011·Human Reproduction Update·B C J M FauserC M Howles
Jul 13, 2007·Current Opinion in Obstetrics & Gynecology·Marie Nam Menke, Jerome F Strauss
Feb 17, 2007·Clinical Obstetrics and Gynecology·Marie Nam Menke, Jerome F Strauss
Aug 16, 2013·Obstetrical & Gynecological Survey·Jaya MehtaDaniel Dumesic
Jul 26, 2012·International Journal of Endocrinology·Carlos MoranSegundo Moran
Sep 9, 2011·International Journal of Pediatric Endocrinology·David H GellerUNKNOWN of the Drug and Therapeutics Committee of the Pediatric Endocrine Society
Apr 30, 2009·The Journal of Clinical Endocrinology and Metabolism·Margrit UrbanekAndrea Dunaif
May 2, 2012·The Journal of Clinical Endocrinology and Metabolism·Corrine K WeltKari Stefansson
May 31, 2014·Human Reproduction·Y V LouwersJ S E Laven
Jul 16, 2014·Nature Reviews. Endocrinology·Channa N Jayasena, Stephen Franks
Jul 30, 2014·Eating and Weight Disorders : EWD·Laura PalaCarlo Maria Rotella
Nov 26, 2014·European Journal of Endocrinology·Simona GaberščekElisabeth Lerchbaum
Aug 26, 2009·Women's Health·Angelica Lindén Hirschberg
Jan 17, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ilay GozukaraKenan Dolapcioglu
Jan 27, 2015·International Journal of Molecular Sciences·Chun FengShi-Wen Jiang
Feb 15, 2016·Reproductive Biomedicine Online·Livio CasariniGiulia Brigante
Oct 27, 2015·Biochemical Pharmacology·Sameer S Udhane, Christa E Flück
Nov 18, 2015·Human Reproduction·Hyejin LeeHye Won Chung
Jun 19, 2013·Metabolism: Clinical and Experimental·Helena TeedeLisa Moran
Dec 10, 2015·Journal of Assisted Reproduction and Genetics·Xin HuangHuangguan Dai
Feb 2, 2013·Molecular and Cellular Endocrinology·David H AbbottDaniel A Dumesic
Oct 23, 2012·Molecular and Cellular Endocrinology·Vasantha Padmanabhan, Almudena Veiga-Lopez
Oct 20, 2012·Molecular and Cellular Endocrinology·Gülüm Kosova, Margrit Urbanek

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved