Heritability of pulmonary function estimated from genome-wide SNPs in healthy Japanese adults

Respiratory Investigation
Hideyasu YamadaNobuyuki Hizawa

Abstract

Pulmonary function is a heritable trait, and recent genome-wide association studies (GWASs) have identified a number of loci influencing the trait. Genome-wide Complex Trait Analysis (GCTA) is a novel method provided by a software package that estimates the total additive genetic influence caused by common single nucleotide polymorphisms (SNPs) on whole-genome arrays. We conducted a GWAS and assessed the heritability of pulmonary function in an adult Japanese population using this approach. We initially conducted a GWAS on %forced vital capacity (FVC), %forced expiratory volume (FEV1) and FEV1/FVC in healthy Japanese adults (N=967). We then examined the heritability of these traits using GCTA with a total of 480,026 SNPs. We also estimated the genetic impact of the 24 genes identified as susceptibility genes to FEV1/FVC in six previous GWASs on the heritability of FEV1/FVC in the Japanese population. The heritabilities for %FVC, %FEV1, and FEV1/FVC were 71.2%, 51.9% and 41.6%, respectively. These results corresponded to previous heritability estimates for pulmonary function obtained by GCTA or by twin studies. The 24 previously reported pulmonary function genes accounted for 4.3-12.0% of the entire estimated heritability of FEV...Continue Reading

References

Jul 25, 2009·Allergology International : Official Journal of the Japanese Society of Allergology·Nobuyuki Hizawa
Dec 17, 2009·Nature Genetics·Emmanouela RepapiMartin D Tobin
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Apr 7, 2011·International Journal of Chronic Obstructive Pulmonary Disease·Hironori MasukoNobuyuki Hizawa
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Jul 28, 2012·American Journal of Respiratory and Critical Care Medicine·Jemma B WilkBruno H Stricker
Oct 17, 2012·Molecular Autism·Lambertus KleiBernie Devlin
May 7, 2013·American Journal of Human Genetics·Anastasia L WiseTeri A Manolio
Aug 13, 2013·The Journal of Allergy and Clinical Immunology·Tsung-Chieh YaoCarole Ober
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Sep 24, 2013·Frontiers in Genetics·Yann C KlimentidisVictor J Thannickal
Jan 17, 2014·The Lancet. Respiratory Medicine·Janet StocksSamatha Sonnappa

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Citations

Mar 25, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N Hizawa
Jan 12, 2016·PloS One·Hideyasu YamadaNobuyuki Hizawa
Mar 14, 2018·American Journal of Respiratory and Critical Care Medicine·Michael Cho, Kelan Tantisira
Jan 9, 2020·COPD·Hideyasu YamadaNobuyuki Hizawa

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