Heritability of the human connectome: A connectotyping study.

Network Neuroscience
Oscar Miranda-DominguezDamien A Fair

Abstract

Recent progress in resting-state neuroimaging demonstrates that the brain exhibits highly individualized patterns of functional connectivity-a "connectotype." How these individualized patterns may be constrained by environment and genetics is unknown. Here we ask whether the connectotype is familial and heritable. Using a novel approach to estimate familiality via a machine-learning framework, we analyzed resting-state fMRI scans from two well-characterized samples of child and adult siblings. First we show that individual connectotypes were reliably identified even several years after the initial scanning timepoint. Familial relationships between participants, such as siblings versus those who are unrelated, were also accurately characterized. The connectotype demonstrated substantial heritability driven by high-order systems including the fronto-parietal, dorsal attention, ventral attention, cingulo-opercular, and default systems. This work suggests that shared genetics and environment contribute toward producing complex, individualized patterns of distributed brain activity, rather than constraining local aspects of function. These insights offer new strategies for characterizing individual aberrations in brain function and ...Continue Reading

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Citations

Sep 15, 2018·Network Neuroscience·Oscar Miranda-DominguezDamien A Fair
Apr 19, 2019·Brain Connectivity·Ruibin ZhangTatia M C Lee
Sep 15, 2018·Network Neuroscience·Olaf Sporns, Danielle S Bassett
Jul 30, 2019·Frontiers in Psychology·David Bueno
Jul 2, 2019·Biomedical Optics Express·Júlia de Souza RodriguesClaudinei Eduardo Biazoli Júnior
Feb 23, 2019·Network Neuroscience·Lisa Byrge, Daniel P Kennedy
Feb 23, 2018·Nature Communications·Monica D RosenbergAvram J Holmes
Oct 10, 2020·Human Brain Mapping·Carla Silva-BatistaOscar Miranda-Domínguez
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Nov 13, 2020·Developmental Cognitive Neuroscience·Kristina M RapuanoB J Casey
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Jan 24, 2021·NeuroImage·Takuya HayashiDavid C Van Essen
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Jul 22, 2021·Cerebral Cortex·Gránit KastratiKarin B Jensen
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Aug 31, 2021·The European Journal of Neuroscience·João Ricardo SatoAndrea Parolin Jackowski
Sep 17, 2021·Communications Biology·Oualid BenkarimBoris C Bernhardt
Oct 1, 2021·Nature Communications·Jason da Silva CastanheiraSylvain Baillet

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Software Mentioned

Matlab
fMRI
FreeSurfer
Connectotyping
Rs

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