Heritability of young- and old-onset ischaemic stroke

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
A BluherY C Cheng

Abstract

Although the genetic contribution to stroke risk is well known, it remains unclear if young-onset stroke has a stronger genetic contribution than old-onset stroke. This study aims to compare the heritability of ischaemic stroke risk between young and old, using common genetic variants from whole-genome array data in population-based samples. This analysis included 4050 ischaemic stroke cases and 5765 controls from six study populations of European ancestry; 47% of cases were young-onset stroke (age < 55 years). To quantify the heritability for stroke risk in these unrelated individuals, the pairwise genetic relatedness was estimated between individuals based on their whole-genome array data using a mixed linear model. Heritability was estimated separately for young-onset stroke and old-onset stroke (age ≥ 55 years). Heritabilities for young-onset stroke and old-onset stroke were estimated at 42% (±8%, P < 0.001) and 34% (±10%, P < 0.001), respectively. Our data suggest that the genetic contribution to the risk of stroke may be higher in young-onset ischaemic stroke, although the difference was not statistically significant.

References

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Citations

Nov 25, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A H V Schapira
Jan 27, 2017·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Feb 14, 2018·Stroke; a Journal of Cerebral Circulation·Sylvia Wassertheil-SmollerJordan W Smoller
Jan 18, 2018·Stroke; a Journal of Cerebral Circulation·Katherine M CrawfordUNKNOWN International Stroke Genetics Consortium
Apr 18, 2020·Genes and Immunity·Isha S DhandePeter A Doris
Aug 4, 2018·Korean Circulation Journal·Jang Whan Bae
Aug 4, 2018·Korean Circulation Journal·Keum Ji JungSun Ha Jee
Apr 20, 2021·PloS One·John W ColeCaspar Grond-Ginsbach
May 22, 2021·Journal of the American College of Cardiology·Clint L MillerJason C Kovacic

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