PMID: 15346682Sep 7, 2004Paper

Heritable anomalies among the inhabitants of regions of normal and high background radiation in Kerala: results of a cohort study, 1988-1994

International Journal of Health Services : Planning, Administration, Evaluation
V T PadmanabhanK Pavithran

Abstract

In a genetic epidemiological and fertility survey among 70,000 inhabitants in a high-background radiation region (HBRR) and normal radiation region (NRR) in Kerala, India, 985 persons were found to have heritable anomalies. Suggested etiologies for the anomalies were chromosomal and Mendelian, 15 percent; multifactorial, 60 percent; and congenital, 25 percent. There was a statistically significant increase of Down syndrome, autosomal dominant anomalies, and multifactorial diseases and an insignificant increase of autosomal recessive and X-linked recessive anomalies in the HBRR. The total fertility rate was 3.85 per couple; 9 percent of live-born children were reported dead. The rate of untoward pregnancy outcome--death of the offspring or presence of an anomaly in a living child--was 6.4 percent among the unrelated couples in the NRR, with one spouse born outside the area of current residence ("migrant"). Considering this as the base, the excess relative risks in the other groups are: "NRR-nonmigrant," 35 percent; "HBRR-nonmigrant," 69 percent; "NRR-consanguineous," 76 percent; and "NBRR-consanguineous," 157 percent. Ionizing radiation, consanguinity, and nearness of birthplace of the spouse are risk factors for the death of of...Continue Reading

References

Oct 1, 1977·Journal of Medical Genetics·C O Carter
Jul 1, 1977·Annals of Human Genetics·P S Rao, S G Inbaraj
Oct 1, 1992·Clinical Cardiology·P Zachariah
Jan 5, 1989·The New England Journal of Medicine·K Nelson, L B Holmes
Jun 1, 1985·American Journal of Medical Genetics·T CostaB Childs
Jan 1, 1966·Special Report Series·H GrünebergR A Weiss
Jan 1, 1982·Annual Review of Genetics·C Denniston
Sep 11, 1981·Science·W J SchullJ V Neel
Dec 1, 1996·International Journal of Epidemiology·V R KuttyC C Kartha

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Citations

Feb 22, 2011·Environmental Science and Pollution Research International·Hagen Scherb, Kristina Voigt
May 6, 2009·Medicine, Conflict, and Survival·Chris BusbyInge Schmitz-Feuerhake
Nov 10, 2012·Biological Reviews of the Cambridge Philosophical Society·Anders P Møller, Timothy A Mousseau
May 22, 2008·Human Heredity·S HarlapY Friedlander
Aug 30, 2005·Environmental Health : a Global Access Science Source·Rita HindinBindu Panikkar
Aug 30, 2008·International Journal of Health Services : Planning, Administration, Evaluation·Rosalie Bertell
Oct 3, 2007·Mental Retardation and Developmental Disabilities Research Reviews·Stephanie L ShermanSallie B Freeman
Sep 30, 2005·Cytogenetic and Genome Research·S L ShermanN E Lamb

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