Heritable DNA methylation marks associated with susceptibility to breast cancer

Nature Communications
Jihoon E JookConFab

Abstract

Mendelian-like inheritance of germline DNA methylation in cancer susceptibility genes has been previously reported. We aimed to scan the genome for heritable methylation marks associated with breast cancer susceptibility by studying 25 Australian multiple-case breast cancer families. Here we report genome-wide DNA methylation measured in 210 peripheral blood DNA samples provided by family members using the Infinium HumanMethylation450. We develop and apply a new statistical method to identify heritable methylation marks based on complex segregation analysis. We estimate carrier probabilities for the 1000 most heritable methylation marks based on family structure, and we use Cox proportional hazards survival analysis to identify 24 methylation marks with corresponding carrier probabilities significantly associated with breast cancer. We replicate an association with breast cancer risk for four of the 24 marks using an independent nested case-control study. Here, we report a novel approach for identifying heritable DNA methylation marks associated with breast cancer risk.

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Citations

Oct 28, 2019·Pathology Oncology Research : POR·Pablo GargalloAdela Cañete
Jun 5, 2020·Epigenomics·Veronika SuniLaura L Elo
May 19, 2019·Breast Cancer Research : BCR·Clara BodelonMontserrat Garcia-Closas
Mar 12, 2020·Cells·Marta Machnik, Urszula Oleksiewicz
May 13, 2020·Cancer Metastasis Reviews·Alejandra I FerrerPranela Rameshwar
Aug 23, 2018·The Prostate·Pierre-Antoine DuguéMelissa C Southey
Mar 1, 2020·Scientific Reports·Randi K JohnsonJill M Norris
Nov 30, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Zhong GuanHermann Brenner
Jun 9, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Justin ChenMichael P Snyder
Nov 24, 2020·Journal of Molecular Biology·Yucong YuXiaobing Shi
Nov 2, 2020·BMC Cancer·Kaoutar Ennour-IdrissiCaroline Diorio
Feb 20, 2021·Journal of Cancer Research and Clinical Oncology·Mangala Hegde, Manjunath B Joshi
Apr 4, 2021·International Journal of Molecular Sciences·Pierre-Antoine DuguéMelissa C Southey
Apr 17, 2021·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Yulong LiXiaojun Yang
Jul 3, 2021·International Journal of Environmental Research and Public Health·Steffen MuellerShujun Liu
Aug 10, 2021·F1000Research·Rafael Sebastián Fort, María Ana Duhagon
Aug 20, 2021·Molecular Oncology·Jacob K KresovichJack A Taylor
Aug 29, 2020·Seminars in Cancer Biology·Gulab SherShahab Uddin

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Methods Mentioned

BETA
PCR
chips

Software Mentioned

HM450 K Manifest
minfi
SWAN
R

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