Heritable formation of neuroectodermal tumor in transgenic mice carrying the combined E1 region gene of adenovirus type 12 with the deregulated human renin promoter

Journal of Cellular Biochemistry
F SugiyamaA Fukamizu

Abstract

Adenovirus early 1 (E1) region gene products, including E1A and E1B, are required for transcriptional regulation of viral and cellular promoters in infected and transfected culture cells and for transformation of primary rodent cells. Here, we established a line of transgenic mice carrying the E1 region gene of human adenovirus type 12 under the control of the human renin promoter, in which a neuroectodermal tumor derived from retroperitoneal, olfactory, and/or pelvic regions was heritably developed with varying degrees of incidence and the phenotype was successfully passed through six generations. The transgenes were located in the region E2-E3 bands of chromosome 7 with which no genetic linkage to neuroectodermal tumors was previously demonstrated, and expressed only in the tumors but not in another tissue examined. Notably, in addition to the expression of a neural marker gene N-CAM, the three nuclear oncogenes, c-, L-, and N-myc, were coexpressed in the tumors. These results suggest that E1A and E1B are cooperatively involved in the heritable formation of neuroectodermal tumors associated with co-expression of the three sets of myc family genes.

References

Jul 15, 1992·Cancer Genetics and Cytogenetics·I J Urumov, Y Manolova
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·L RaoE White
Jan 1, 1992·Cytogenetics and Cell Genetics·Y MatsudaV M Chapman
Sep 1, 1991·Molecular and Cellular Biology·D G SkalnikS H Orkin
Feb 15, 1990·Nature·J J WindleP L Mellon
Jan 1, 1991·Advances in Cancer Research·T Shenk, J Flint
Jul 1, 1991·Journal of Clinical Pathology·E PhimisterK Patel
Sep 1, 1991·The Biochemical Journal·A FukamizuK Murakami
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J A SmallG A Scangos
Dec 15, 1989·Biochemical and Biophysical Research Communications·A FukamizuK Murakami
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K KoikeG Jay
Dec 8, 1989·Science·D Hanahan
Jan 1, 1986·Annual Review of Genetics·A J Berk
Jan 1, 1984·Pharmacology & Therapeutics·S J Flint
Jan 1, 1980·Cold Spring Harbor Symposia on Quantitative Biology·P H Gallimore, C Paraskeva
Apr 1, 1993·Genes & Development·M Debbas, E White
Jan 1, 1993·Advances in Cancer Research·P I Schrier, L T Peltenburg
Mar 1, 1993·British Journal of Cancer·T IwamotoM Takahashi
Sep 14, 1962·Science·J J TRENTING TAYLOR

❮ Previous
Next ❯

Citations

Oct 1, 1995·Trends in Endocrinology and Metabolism : TEM·A Fukamizu, K Murakami

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.