PMID: 2105500Feb 1, 1990Paper

Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus

Proceedings of the National Academy of Sciences of the United States of America
C O JacobH O McDevitt

Abstract

We report on the production of tumor necrosis factor (TNF)-alpha and TNF-beta by mitogen-activated peripheral blood lymphocytes or enriched monocyte subpopulations from human leukocyte antigen (HLA)-typed healthy subjects. The results indicate that HLA-DR2- and DQw1-positive donors frequently exhibit low production of TNF-alpha, whereas DR3- and DR4-positive subjects show high levels of TNF-alpha production. No correlation between TNF-alpha levels and HLA-A, -B, and -C genotype was found. The relevance of this quantitative polymorphism to the genetic predisposition to lupus nephritis in systemic lupus erythematosus (SLE) patients was investigated. DR2, DQw1-positive SLE patients show low levels of TNF-alpha inducibility; this genotype is also associated with an increased incidence of lupus nephritis. DR3-positive SLE patients, on the other hand, are not predisposed to nephritis, and these patients have high TNF-alpha production. DR4 haplotype is associated with high TNF-alpha inducibility and is negatively correlated with lupus nephritis. These data may help explain the strong association between HLA-DR2, DQw1 in SLE patients and their susceptibility to nephritis.

References

Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A CarswellB Williamson
Dec 23, 1988·The American Journal of Medicine·Z FronekH O McDevitt
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·I DunhamR D Campbell
Nov 1, 1988·The Journal of Experimental Medicine·S S SungS M Fu
Feb 1, 1988·The Journal of Rheumatology·J C Woodrow
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T SpiesJ L Strominger
Jan 1, 1986·Cold Spring Harbor Symposia on Quantitative Biology·D V GoeddelB J Sugarman
Feb 12, 1987·The New England Journal of Medicine·B Beutler, A Cerami
Nov 6, 1986·Journal of Immunological Methods·S M Kramer, M E Carver
Dec 1, 1968·The Journal of Experimental Medicine·N H Ruddle, B H Waksman
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester

❮ Previous
Next ❯

Citations

Nov 11, 1999·Arthritis and Rheumatism·D N Glass, E H Giannini
Jan 31, 2002·Arthritis and Rheumatism·George MoxleyMichael C Neale
Nov 1, 1995·Annals of Neurology·S L Hauser
Sep 1, 1995·Electrophoresis·C EpplenJ T Epplen
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S CooksonP T Donaldson
Jan 1, 1991·Immunogenetics·P ChardonM Vaiman
Mar 1, 1991·Journal of Clinical Immunology·C L Miller-GrazianoD Catalano
Jun 1, 1996·Human Genetics·B M BrinkmanC L Verweij
Oct 7, 2003·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Dongxian LiuXingping Chen
Jan 1, 1991·Immunologic Research·P F PiguetP Vassalli
Mar 25, 2010·Rheumatology International·Yan-Feng ZouDong-Qing Ye
Feb 26, 2013·Journal of Clinical Immunology·Xu-yan YangQing-qing Wang
Jan 1, 1991·Journal of Reproductive Immunology·S S WitkinZ Rosenwaks
Oct 1, 1991·Immunology Letters·J LevineD I Beller
Feb 1, 1994·International Journal of Immunopharmacology·G SzaboC L Miller-Graziano
Oct 1, 1991·Current Opinion in Immunology·H F Oettgen
Mar 31, 2004·Joint, Bone, Spine : Revue Du Rhumatisme·Bénédicte Mugnier, Jean Roudier

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.