Heroes or villains? T regulatory cells in malaria infection

Trends in Parasitology
Anja ScholzenMagdalena Plebanski

Abstract

Infection with Plasmodium parasites can cause severe disease due to a lack of protective immune responses to clear parasitemia, or to the host's inability to control excessive inflammation resulting in immunopathology. T regulatory cells (Tregs), key mediators of immune homeostasis, are increased in number and modulate disease in human and murine malaria. Several recent studies provide new insights into the mechanisms and functional consequences of Treg induction by P. falciparum. This review integrates and discusses the findings published on Tregs in human and murine malaria to date, with emphasis on Treg induction (host components, kinetics and parasite-dependence) and their diverse roles (protective or pathological) during infection.

References

Dec 17, 2002·International Archives of Allergy and Immunology·Megan K LevingsMaria Grazia Roncarolo
Mar 14, 2003·International Journal for Parasitology·Ton That Ai LongHiroji Kanbara
Jan 2, 2004·Nature Medicine·Hajime HisaedaKoji Yasutomo
Nov 13, 2004·Immunity·Chandrashekhar Pasare, Ruslan Medzhitov
Jan 5, 2005·The Journal of Experimental Medicine·Cevayir CobanShizuo Akira
Mar 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Santiago ZelenayJocelyne Demengeot
May 24, 2005·Infection and Immunity·Zhong SuMary M Stevenson
Jul 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Blandine Franke-FayardAndrew P Waters
Mar 25, 2006·Expert Reviews in Molecular Medicine·Tracey J LambJean Langhorne
Jan 11, 2007·Scandinavian Journal of Immunology·A Ramos-AvilaM Legorreta-Herrera
Jan 31, 2007·Proceedings of the National Academy of Sciences of the United States of America·Peggy ParrocheDouglas T Golenbock
Mar 14, 2007·International Journal for Parasitology·Ana Margarida VigárioSylviane Pied
Apr 19, 2007·Nature Immunology·Ye Zheng, Alexander Y Rudensky
Apr 26, 2007·The American Journal of Pathology·Dieudonnée TogbeBernhard Ryffel
Jun 5, 2007·Immunobiology·Elly van RietMaria Yazdanbakhsh
Jun 15, 2007·European Journal of Immunology·Constance A M FinneyRick M Maizels
Jun 30, 2007·The American Journal of Pathology·Fiona H AmanteChristian R Engwerda
Aug 4, 2007·Science·Shimon Sakaguchi, Fiona Powrie
Oct 20, 2007·Nature Reviews. Immunology·Yasmine Belkaid
Nov 1, 2007·European Journal of Immunology·Shimon SakaguchiMakoto Miyara
Nov 17, 2007·The Journal of Infectious Diseases·Jason W GriffithRichard Bucala
Jan 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Maria G TorciaDavid Modiano
Feb 21, 2008·Nature Immunology·Qizhi Tang, Jeffrey A Bluestone
Jun 11, 2008·Pediatrics·Chandy C JohnMichael J Boivin
Jun 20, 2008·Nature Immunology·Jean LanghorneKevin Marsh
Aug 20, 2008·Nature Reviews. Microbiology·Michelle N Wykes, Michael F Good
Oct 1, 2008·European Journal of Immunology·Kulachart JangpatarapongsaRachanee Udomsangpetch
Mar 24, 2009·Annual Review of Immunology·Yasmine Belkaid, Kristin Tarbell
Apr 2, 2009·European Journal of Immunology·Olivia C FinneyEleanor M Riley
Apr 28, 2009·The Journal of Infectious Diseases·Franca C HartgersMaria Yazdanbakhsh
May 26, 2009·Immunity·Maria A Curotto de Lafaille, Juan J Lafaille

❮ Previous
Next ❯

Citations

Apr 5, 2011·HIV Therapy·Bernard Jc Macatangay, Charles R Rinaldo
Apr 26, 2014·Parasitology Research·Yang ChengEun-Taek Han
Mar 30, 2010·Critical Care : the Official Journal of the Critical Care Forum·Eirini Christaki, Eleni Patrozou
Jan 9, 2016·Parasitology·Danielle I Stanisic, Michael F Good
Feb 3, 2016·The Journal of Experimental Medicine·Jean Langhorne, Patrick E Duffy
Jul 13, 2012·Cellular Immunology·Henrique Borges da SilvaCarlos E Tadokoro
May 3, 2011·Trends in Parasitology·Bruno Douradinha, Denise L Doolan
Mar 15, 2011·Pathology, Research and Practice·Nicola DanieleFrancesco Zinno
Jun 5, 2012·Current Opinion in Immunology·Philip J Spence, Jean Langhorne
Oct 14, 2014·Frontiers in Microbiology·Jorjoh Ndure, Katie L Flanagan
Mar 15, 2012·Memórias do Instituto Oswaldo Cruz·Haroon AkbarNathalie Moiré
Jan 3, 2019·Expert Review of Vaccines·K L WilsonM Plebanski
Apr 12, 2019·Parasite Immunology·Ann M MoormannCatherine S Forconi
Dec 5, 2019·Parasite Immunology·Rafaella Oliveira Dos SantosPritesh Lalwani
Feb 1, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria S MackrothChristopher L King
Sep 7, 2017·Scientific Reports·Norinne Lacerda-QueirozXin-Zhuan Su
Jul 14, 2010·Expert Review of Vaccines·Cevayir CobanKen J Ishii
Feb 19, 2019·Frontiers in Immunology·Aloysious SsemagandaMichael F Good
Mar 11, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Floriana BerrettaMary M Stevenson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.