Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum

Brain Research
Loredana D'EsteTindaro G Renda

Abstract

Immunohistochemistry was used to map the induction of c-Fos protein in the forebrain of rats treated with heroin. Acute injection of heroin to drug-naive rats caused significant induction of c-Fos protein in the nucleus accumbens shell, whereas the same dose of heroin given to drug-sensitized rats significantly increased c-Fos immunoreactivity in the dorsomedial caudate-putamen. These results show that the heroin-induced pattern of c-Fos protein in the rat striatum differs according to the rat's drug history. These findings may represent a neural correlate of the motor components of heroin sensitization.

Citations

May 28, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Malini E SinghPaul E Mallet
May 27, 2004·Natural Product Reports·Kenneth W Bentley
Mar 30, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Giovanna PaoloneAldo Badiani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.