PMID: 58951Jun 1, 1976

Herpes gestationis. Ultrastructure and ultrastructural localization of in vivo-bound complement

The Journal of Investigative Dermatology
H YaoitaS I Katz

Abstract

Ultrastructural localization of C3 deposition in the skin of two patients with herpes gestationis was determined by using a peroxidase-antiperoxidase multistep technique. The tissue preparations can be stored for long periods of time and identical sections may be used for light and electron microscopic examination. The reaction products were seen throughout the entire lamina lucida and the basal cell plasma membrane appeared to be accentuated. The most remarkable ultrastructural changes in normal-appearing skin were the destruction of the basal cell membranes on the dermal side, localized cytoplasmic dissolution, and intracellular edema unaccompanied by inflammatory cells. Early, nonvesicular lesions showed basal cell degeneration and dermal inflammatory cells. Necrosis and loss of basal cells occurred in the next stage which resulted in microvesicles in which collagen or a well-preserved basal lamina formed the vesicle base. In the later blister stage, the basal lamina was usually lost. It is suggested that damage of basal cell membranes on their dermal side leads to the destruction of basal cells with the subsequent protrusion of epidermal and junctional substances into the dermis. This may result in inflammatory cell infiltr...Continue Reading

Citations

Jun 1, 1978·Clinical and Experimental Dermatology·J A Carruthers
Dec 1, 1977·The Australasian Journal of Dermatology·D Weedon
Oct 27, 1977·Archives of Dermatological Research·O Braun-FalcoR Scherer
Sep 1, 1985·International Journal of Dermatology·E H BeutnerS Jablonska
Mar 1, 1982·Clinical and Experimental Dermatology·T P Cutler
Aug 1, 1983·The Journal of Dermatology·A MatsukawaH Yaoita
Aug 1, 1980·The Australasian Journal of Dermatology·A B Watson
Mar 1, 1994·Clinical and Experimental Dermatology·G Kirtschig, F Wojnarowska
Apr 1, 1979·The British Journal of Dermatology·C I Harrington, S S Bleehen
May 1, 1986·International Journal of Dermatology·G Schaumburg-Lever
Aug 1, 1980·The Australasian Journal of Dermatology·A J Cooper, J A Fryer
May 1, 1981·The British Journal of Dermatology·E EberstA Basset
May 1, 1981·International Journal of Dermatology·D SassevilleJ Y Schnader
Dec 1, 1985·The Australasian Journal of Dermatology·M V Dahl
May 1, 1979·International Journal of Dermatology·R E Jordon, L L Bushkell
May 1, 1988·The British Journal of Dermatology·S E KellyM M Black
Jan 1, 1986·International Journal of Dermatology·H N LiuR S Rogers
Feb 1, 1981·British Journal of Obstetrics and Gynaecology·J M FoidartS I Katz
Jun 1, 1982·The Journal of Dermatology·S MiyagawaK Sakamoto

Related Concepts

Hemolytic Complement
Complement C3 precursor
Pemphigoid Gestationis
Alpha-Peroxidase
Pemphigus Foliaceus
Pregnancy Complications
Skin
Vesicular Skin Diseases
Staining and Labeling

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