PMID: 9431533Feb 12, 1998Paper

Herpes labialis in skiers: randomized clinical trial of acyclovir cream versus placebo

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
G W RabornW T McGaw

Abstract

A randomized, double-blind trial at seven ski sites in Canada and the United States was conducted to compare the effectiveness and the patient tolerance of topically applied 5% acyclovir cream (MAC III formulation) with those of a placebo cream in the prevention of sun-induced herpes labialis lesions. All subjects had experienced more than three episodes of sun-induced herpes labialis during the previous year. There were 196 subjects enrolled; 5 did not receive medication, and 10 were excluded from the efficacy analysis for protocol violations. There were 191 subjects in the intent-to-treat analysis, and a separate efficacy analysis was done on 181 subjects. Log rank and Fisher exact tests were used in the analysis. There was no difference between the two groups at baseline with respect to any clinical or demographic factor. There was no substantial difference between the groups with respect to adverse experiences (15 for acyclovir; 13 for the placebo). The acyclovir group had significantly fewer lesions (p < 0.01) than the placebo group (21% vs. 40%) during the 4-day follow-up period. The acyclovir group was significantly better than the placebo group during the follow-up period. The safety record of the drug was satisfactory;...Continue Reading

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Citations

Sep 28, 2002·The Journal of Infectious Diseases·A LaiskonisE Hiltunen-Back
Dec 2, 2004·Expert Opinion on Pharmacotherapy·Daniel T Leung, Stephen L Sacks
Mar 10, 2010·Expert Opinion on Pharmacotherapy·Nathaniel S Treister, Sook-Bin Woo
May 6, 2004·International Journal of Dermatology·Andrei MetelitsaAndrew N Lin
Oct 8, 2005·Seminars in Pediatric Infectious Diseases·David W Kimberlin
Feb 13, 2004·The Journal of the American Dental Association·G Wayne RabornMichael Grace
Apr 6, 2002·The Journal of the American Dental Association·G Wayne RabornUNKNOWN Worldwide Topical Penciclovir Collaborative Study Group
Jun 7, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Hanieh RahimiRichard Bohay
Aug 8, 2015·The Cochrane Database of Systematic Reviews·Ching-Chi ChiPreetha P Kanjirath
Jun 5, 2001·Current Opinion in Pediatrics·A Sonis, S Zaragoza

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