Herpes simplex inhibits the capacity of lymphoblastoid B cell lines to stimulate CD4+ T cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
S Barcy, L Corey

Abstract

HSV establish a lifelong persistent infection in their host even among immunocompetent persons. The viruses use a variety of immune evasion strategies, presumably to assist persistent replication in the human host. We have observed that infection of human B lymphoblastoid cells (B-LCL) by HSV resulted in a strong inhibition of their ability to induce CD4(+) T cell clone proliferation and cytokine secretion. This inhibitory effect occurs in a variety of both HSV- and HIV-specific clones from three different patients. The inhibition is observed when the Ag is provided either as a soluble protein or as a synthetic peptide and is not associated with detectable down-modulation of the MHC class II molecules or costimulatory molecules. Expression of the HSV-1 unique sequence 1 gene (US1) is necessary and sufficient to induce this inhibition of APC function. US1 gene expression also made B-LCL less susceptible to CD4(+) T cell-mediated lysis. These data indicate a novel immune evasion strategy by HSV-1 in which Ag-processing cells that become infected by HSV-1 are inhibited in their ability to induce subsequent CD4(+) T cell activation.

References

Feb 1, 1995·International Immunology·S BarcyM de Boer
Apr 3, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R J WhitleyB Roizman
Oct 30, 1999·European Journal of Immunology·M SalioA Lanzavecchia
Jun 3, 2000·Annual Review of Immunology·O Acuto, D Cantrell

❮ Previous
Next ❯

Citations

Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jürgen NeumannNorbert Koch
Dec 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aziz Alami ChentoufiLbachir BenMohamed
Dec 2, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sebastian TemmeNorbert Koch
Jan 26, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Naima NiazyNorbert Koch
Feb 6, 2020·Frontiers in Cellular and Infection Microbiology·Yangguang LiAnchun Cheng
Jan 15, 2003·Clinical Microbiology Reviews·David M Koelle, Lawrence Corey
Feb 24, 2012·Journal of Virology·Maria-D NastkeJ Mauricio Calvo-Calle
Jul 16, 2015·Human Gene Therapy·Dmitriy Zamarin, Sari Pesonen
May 23, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yan YanQinxue Hu
Mar 14, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Werner J D OuwendijkGeorges M G M Verjans
Jan 4, 2006·International Journal of Immunopathology and Pharmacology·M I GonzalezG A Rabinovich
Dec 29, 2004·Ocular Immunology and Inflammation·Lies RemeijerGeorges Verjans

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
J A SchepplerJ S McDougal
Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
M HeinkeleinC Jassoy
Current HIV/AIDS Reports
Susanna Grundström, Jan Andersson
© 2021 Meta ULC. All rights reserved