Herpes Simplex Virus: A Versatile Tool for Insights Into Evolution, Gene Delivery, and Tumor Immunotherapy.

Virology : Research and Treatment
Prapti H ModyJuliet V Spencer

Abstract

Herpesviruses are prevalent throughout the animal kingdom, and they have coexisted and coevolved along with their host species for millions of years. Herpesviruses carry a large (120-230 kb) double-stranded DNA genome surrounded by a protein capsid, a tegument layer consisting of viral and host proteins, and a lipid bilayer envelope with surface glycoproteins. A key characteristic of these viruses is their ability to enter a latent state following primary infection, allowing them to evade the host's immune system and persist permanently. Herpesviruses can reactivate from their dormant state, usually during times of stress or when the host's immune responses are impaired. While herpesviruses can cause complications with severe disease in immune-compromised people, most of the population experiences few ill effects from herpesvirus infections. Indeed, herpes simplex virus 1 (HSV-1) in particular has several features that make it an attractive tool for therapeutic gene delivery. Herpes simplex virus 1 targets and infects specific cell types, such as epithelial cells and neurons. The HSV-1 genome can also accommodate large insertions of up to 14 kb. The HSV-1-based vectors have already achieved success for the oncolytic treatment o...Continue Reading

References

May 1, 1972·Journal of Virology·E KieffB Roizman
Nov 17, 1972·Science·C A FarleyW S Foster
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·G NilaverE A Neuwelt
Mar 21, 1998·The Journal of Experimental Medicine·K GoldsmithR L Hendricks
Aug 8, 1998·Journal of Virology·T A Stavropoulos, C A Strathdee
Oct 6, 2000·Molecular Therapy : the Journal of the American Society of Gene Therapy·M TodaS D Rabkin
Oct 25, 2000·The Journal of Gene Medicine·U HerrlingerS A Reeves
Jul 6, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Veljko PuskovicDavid J Fink
Aug 4, 2004·Cancer Research·Mads Hald AndersenJürgen C Becker
Sep 5, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Veljko PuskovicMarina Mata
Sep 12, 2006·The Journal of General Virology·Efrat BraunIsrael Steiner
Nov 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer C C HuR Charles Coombes
Mar 14, 2008·Current Gene Therapy·Marina MataDavid J Fink
Mar 5, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Bakhos A TannousXandra O Breakefield
May 2, 2009·Science·Sarah A TishkoffScott M Williams
Oct 7, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zetang WuDavid J Fink
Apr 15, 2011·Infectious Disorders Drug Targets·Flore RozenbergHenri Agut
Jul 19, 2011·Future Virology·Miles C SmithDavid J Davido
Jul 26, 2011·Neuro-oncology·T J MacDonaldC M Kramm
Dec 14, 2011·FEMS Microbiology Reviews·Michael P NicollStacey Efstathiou
Dec 14, 2011·Viruses·Larry HansonMoshe Kotler
Mar 30, 2012·The Journal of Infectious Diseases·Monique van VelzenGeorges M G M Verjans
May 9, 2012·Neuroscience Letters·Darren WolfeDavid J Fink
Oct 25, 2012·Anti-cancer Agents in Medicinal Chemistry·Zhaoye WangJuan Sebastian Yakisich
Oct 23, 2013·PloS One·Aaron W KolbCurtis R Brandt
Mar 29, 2014·Methods in Molecular Biology·Matias E MelendezAlberto L Epstein
Jun 12, 2014·Molecular Biology and Evolution·Joel O WertheimSergei L Kosakovsky Pond

❮ Previous
Next ❯

Software Mentioned

bootscan

Related Concepts

Related Feeds

Cell-Type Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Cell-Type-Specific Viral Vectors (ASM)

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Cell-Type-Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Current Topics in Microbiology and Immunology
C Lopez
Fukuoka igaku zasshi = Hukuoka acta medica
Kenichi Umene
© 2021 Meta ULC. All rights reserved