Herpes simplex virus (HSV)-specific T cells activated in the absence of IFN-gamma express alternative effector functions but are not protective against genital HSV-2 infection.

Journal of Reproductive Immunology
Alison J JohnsonGregg N Milligan

Abstract

Interferon gamma (IFNgamma) is important for immune resistance to herpes simplex virus (HSV) infection. To examine the influence of IFNgamma on the development of HSV-specific immune responses and test for IFNgamma-independent adaptive immune mechanisms of protection, IFNgamma-deficient mice (IFNgamma(-/-)) were immunized with thymidine kinase-deficient HSV-2 (HSV-2 333tk(-)). HSV-specific cellular and humoral responses were elicited in immunized IFNgamma(-/-) mice resulting in increased resistance relative to non-immune C57BL/6J (B6) mice following challenge with fully virulent HSV-2. CD8(+) T cells from IFNgamma(-/-) mice displayed cytotoxic activity and secreted TNFalpha. HSV-specific CD4(+) T cells from immunized IFNgamma(-/-) mice secreted IL-4, TNFalpha, and IL-17, but unlike T cells from HSV-immune B6 mice, could not clear virus from genital tissue following adoptive transfer. HSV-immune IFNgamma(-/-) mice produced predominantly IgG(1) HSV-specific antibodies while immune B6 mice produced predominantly IgG(2c) antibodies. Transfer of equivalent amounts of HSV-specific antibodies from either strain to naïve mice imparted equivalent early resistance against infection of the genital epithelia. However, protection against ne...Continue Reading

References

Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·C M PosavadL Corey
May 4, 2000·Virology·K L DudleyG N Milligan
Mar 29, 2003·Journal of Virology·Charu KaushicKenneth L Rosenthal
Mar 17, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Lawrence CoreyThomas C Quinn
Apr 6, 2004·Journal of Reproductive Immunology·Gregg N MilliganChin-Fun Chu
Dec 3, 2008·The Journal of Experimental Medicine·Norifumi IijimaAkiko Iwasaki

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