Herpes simplex virus in bronchoalveolar lavage fluid of medical intensive care unit patients: Association with lung injury and outcome

Journal of Critical Care
Bernd SaugelAndreas Umgelter

Abstract

In intensive care unit (ICU) patients in whom bronchoalveolar lavage fluid (BALF) was analyzed for suspected infectious pulmonary disease, we investigated the association of herpes simplex virus (HSV) in the BALF with lung injury and patient outcome. In this retrospective cohort study, we included 201 patients treated in a medical ICU of a German university hospital in whom BALF samples were analyzed for the presence of HSV using quantitative polymerase chain reaction analysis. Eighty-seven patients (43%) were HSV-negative, and 114 patients (57%) were HSV-positive. At the day of BALF sampling (day 0), there was no clinically relevant (or statistically significant) difference in the Modified Clinical Pulmonary Infection Score, Lung Injury Score, and single indicator transpulmonary thermodilution-derived extravascular lung water index and pulmonary vascular permeability index between HSV-negative patients and HSV-positive patients or HSV-positive patients with greater than 10(5) HSV copies/mL. The ICU and hospital length of stay was statistically significantly longer in HSV-positive patients compared with HSV-negative patients. Intensive care unit and hospital mortality was not statistically significantly different between the gr...Continue Reading

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Citations

Apr 24, 2018·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Dima Dandachi, Maria C Rodriguez-Barradas
Jul 20, 2018·BMJ Case Reports·Toru IshiharaAtsushi Takagi
Jan 12, 2020·Critical Care : the Official Journal of the Critical Care Forum·Lukas SchuiererReinhard Hoffmann

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