PMID: 11920821Mar 29, 2002Paper

Herpes simplex virus isolates with reduced adefovir susceptibility selected in vivo by foscarnet therapy

Journal of Medical Virology
Julie Bestman-Smith, G Boivin

Abstract

Sequential herpes simplex virus (HSV) isolates from AIDS patients receiving foscarnet therapy were evaluated for susceptibility to adefovir. Foscarnet-resistant isolates with DNA polymerase mutations in regions II, VI, and between I and VII were also associated with an important decrease in susceptibility to adefovir (mean IC50 increase: 4.6-fold compared to pre-foscarnet or wild-type isolates) suggesting that adefovir-resistant HSV could be selected in vivo by foscarnet therapy.

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Citations

Jul 24, 2002·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Christian GilbertGuy Boivin
Nov 17, 2010·Antimicrobial Agents and Chemotherapy·Jocelyne Piret, Guy Boivin
Mar 8, 2014·Reviews in Medical Virology·Jocelyne Piret, Guy Boivin
Apr 20, 2016·Veterinary Ophthalmology·Sara M Thomasy, David J Maggs
Jun 14, 2005·Clinical Techniques in Small Animal Practice·David J Maggs
Apr 12, 2015·International Journal of STD & AIDS·Raj PatelElizabeth Foley
Feb 6, 2017·Virus Research·Karima ZarroukGuy Boivin
May 26, 2021·Nature Communications·Robert P HayesDaniel Klein

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