Herpes simplex virus Membrane Fusion

Advances in Anatomy, Embryology, and Cell Biology
Darin J Weed, Anthony V Nicola

Abstract

Herpes simplex virus mediates multiple distinct fusion events during infection. HSV entry is initiated by fusion of the viral envelope with either the limiting membrane of a host cell endocytic compartment or the plasma membrane. In the infected cell during viral assembly, immature, enveloped HSV particles in the perinuclear space fuse with the outer nuclear membrane in a process termed de-envelopment. A cell infected with some strains of HSV with defined mutations spread to neighboring cells by a fusion event called syncytium formation. Two experimental methods, the transient cell-cell fusion approach and fusion from without, are useful surrogate assays of HSV fusion. These five fusion processes are considered in terms of their requirements, mechanism, and regulation. The execution and modulation of these events require distinct yet often overlapping sets of viral proteins and host cell factors. The core machinery of HSV gB, gD, and the heterodimer gH/gL is required for most if not all of the HSV fusion mechanisms.

Citations

Aug 16, 2019·Expert Review of Anti-infective Therapy·Roberta MancusoMario Clerici
Dec 13, 2019·Journal of Virology·Tri Komala SariAnthony V Nicola
Jun 12, 2020·Viruses·Raquel Bello-MoralesJosé Antonio López-Guerrero
Nov 22, 2019·Journal of Virology·José Antonio López-GuerreroRaquel Bello-Morales
Sep 26, 2020·Frontiers in Neurology·Niko HenselPeter Claus
Nov 23, 2019·Viruses·Stephen J Dollery
Feb 7, 2020·MSphere·Tri Komala SariAnthony V Nicola
Jul 24, 2020·Nature Reviews. Neuroscience·Menachem Hanani, David C Spray
Dec 23, 2017·Frontiers in Microbiology·George A WudiriAnthony V Nicola
Oct 9, 2020·Journal of Virology·Giulia TebaldiAnthony V Nicola
Dec 23, 2020·International Journal of Molecular Sciences·Héloïse LeroySerge Benichou
Feb 5, 2021·Frontiers in Cellular and Infection Microbiology·Krishnaraju MadavarajuDeepak Shukla
Feb 23, 2021·Frontiers in Microbiology·Inés RipaRaquel Bello-Morales
Mar 9, 2021·Frontiers in Microbiology·Chunmei LiBin Tian
May 28, 2021·Archives of Virology·Joy MondalDebprasad Chattopadhyay
Jun 3, 2021·Cells·Yuqing WuHeike Grassmé
Jul 3, 2021·Viruses·Guillermo Blanco-Rodriguez, Francesca Di Nunzio
Aug 29, 2021·Viruses·Brent A StanfieldEdward Gershburg

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