PMID: 9194040Jan 1, 1997Paper

Herpes simplex virus-specific IgM, IgA and IgG subclass antibody responses in primary and nonprimary genital herpes patients

Microbiology and Immunology
M Hashido, T Kawana

Abstract

To clarify the humoral immunity in herpes simplex virus (HSV) infection, HSV-specific IgM, IgA and IgG subclass antibody responses were studied in patients with genital herpes: 17 primary, 13 recurrent and 6 nonprimary first episode. A total of 181 serum samples serially collected from the patients, 5 per patient until 213 days after the onset of disease (on average), were analyzed by an enzyme-linked immunosorbent assay. IgG1, IgG3 and IgA were detected in all patients with primary and nonprimary infections, whereas IgG4 was detected in 74% of only those with nonprimary infections and IgG2 was detected in none. IgM was detected in 100% of the patients with primary infections, but also in 68% of those with nonprimary infections. IgA showed a peak similar to that of IgM in patients with primary infections. No significant difference was observed in the detection rate or pattern of antibody responses between the recurrent and nonprimary first episode infections, nor between the HSV-1 and HSV-2 infections. These findings may be useful to improve the diagnostic potential of HSV serology.

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Citations

Sep 10, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M de MartinoA Vierucci
Jun 12, 2001·Viral Immunology·R J Whitley, R L Miller
May 28, 2011·Journal of Theoretical Biology·Vladislav V Khrustalev, Eugene V Barkovsky
May 5, 2009·Veterinary Microbiology·Mariarosaria MarinaroCanio Buonavoglia
Nov 26, 2008·Journal of Medical Virology·Samuel L MurphyKatherine A High
Jan 15, 2003·Journal of Medical Virology·María del Carmen SaavedraAna María Ambrosio
Jan 7, 2003·Viral Immunology·Svetlana F Khaiboullina, Stephen C St Jeor
Nov 28, 2018·Dermatology Practical & Conceptual·Fariba MohammadiPedarm Noormohammadpour
May 23, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yan YanQinxue Hu
Aug 19, 2007·Fetal and Pediatric Pathology·Corinna S BowserJack Moallem

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