Herpes simplex virus type 1 in Europe: systematic review, meta-analyses and meta-regressions.

BMJ Global Health
Wajiha YousufLaith J Abu-Raddad

Abstract

To describe the epidemiology of herpes simplex virus type 1 (HSV-1) in Europe. We systematically reviewed HSV-1 related publications, conducted various meta-analyses and meta-regressions, assessed pooled mean seroprevalence, and estimated pooled mean proportions of HSV-1 viral detection in clinically diagnosed genital ulcer disease (GUD) and in genital herpes. We extracted, from 142 relevant records, 179 overall (622 stratified) seroprevalence measures, 4 overall proportions of HSV-1 in GUD and 64 overall (162 stratified) proportions of HSV-1 in genital herpes. Pooled mean seroprevalence was 67.4% (95% CI 65.5% to 69.3%) with 32.5% (95% CI 29.4% to 35.7%) of children and 74.4% (95% CI 72.8% to 76.0%) of adults infected. Pooled seroprevalence increased steadily with age, being lowest in those aged <20 years (39.3%, 95% CI 35.9% to 42.7%) and highest in those aged >50 years (82.9%, 95% CI 78.8% to 86.6%). Pooled seroprevalence decreased yearly by 0.99-fold (95% CI 0.99 to 1.00). Pooled mean proportion of HSV-1 detection was 13.6% (95% CI 4.1% to 27.1%) in GUD, 34.1% (95% CI 31.7% to 36.5%) in genital herpes and 49.3% (95% CI 42.2% to 56.4%) in first episode genital herpes. Pooled proportion of HSV-1 detection in genital herpes in...Continue Reading

References

Nov 14, 1981·Lancet·I G BartonE B Turner
Mar 1, 1995·International Journal of STD & AIDS·C A Rodgers, C O'Mahony
Oct 27, 1997·The New England Journal of Medicine·D T FlemingM E St Louis
Aug 17, 1999·Sexually Transmitted Infections·M ArvajaT Vesikari
Sep 28, 2002·The Journal of Infectious Diseases·Jennifer S Smith, N Jamie Robinson
Oct 2, 2003·Sexually Transmitted Diseases·Zmira SamraMichael Dan
Dec 13, 2003·Antiviral Research·Rebecca C Brady, David I Bernstein
Jun 12, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·R Ashley-MorrowJ Smith
Jun 1, 2005·Sexually Transmitted Infections·D N Fisman
Oct 18, 2007·Journal of the American Academy of Dermatology·Mahnaz Fatahzadeh, Robert A Schwartz
Dec 25, 2007·Lancet·Rachna GuptaAnna Wald
Jun 23, 2009·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Hayley MarkJoy Nanda
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Oct 23, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David I BernsteinRobert B Belshe
Oct 19, 2013·The Journal of Infectious Diseases·Heather BradleyGeraldine M McQuillan
Feb 1, 2014·Vaccine·Nathalie BroutetUNKNOWN participants of the 2013 STI Vaccine Technical Consultation
Aug 26, 2014·Best Practice & Research. Clinical Obstetrics & Gynaecology·Suzanne M Garland, Marc Steben
Nov 12, 2016·Sexually Transmitted Diseases·Meena RamchandaniAnna Wald
Jul 19, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lara KhadrLaith J Abu-Raddad
Aug 4, 2019·The Journal of Infection·Manale HarfoucheLaith J Abu-Raddad
Nov 7, 2019·Sexually Transmitted Diseases·Nazila DabestaniChristine Johnston
Nov 26, 2019·Sexually Transmitted Diseases·Nazila DabestaniChristine Johnston
Jun 10, 2020·Bulletin of the World Health Organization·Charlotte JamesKatharine J Looker

❮ Previous
Next ❯

Citations

Jun 20, 2021·MMW Fortschritte der Medizin·Stefanie Sammet, Stefan Esser
Sep 26, 2021·Journal of Paediatrics and Child Health·Angela BerkhoutClare Nourse

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme linked immunosorbent

Software Mentioned

metareg
R
SE
Stata
Embase

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.