PMID: 9420243Jan 7, 1998Paper

Herpes simplex virus type 1 renders infected cells resistant to cytotoxic T-lymphocyte-induced apoptosis

Journal of Virology
Keith R JeromeL Corey

Abstract

Many viruses interfere with apoptosis of infected cells, presumably preventing cellular apoptosis as a direct response to viral infection. Since cytotoxic T lymphocytes (CTL) induce apoptosis of infected cells as part of the "lethal hit," inhibition of apoptosis could represent an effective immune evasion strategy. We report here herpes simplex virus type 1 (HSV-1) interference with CTL-induced apoptosis of infected cells and show that HSV-1 inhibits the nuclear manifestations of apoptosis but not the membrane changes. The HL-60 cell line (human promyelocytic leukemia) undergoes apoptosis in response to many stimuli, including incubation with ethanol. After HSV-1 infection (strains E115 and 17+), ethanol-treated cells did not produce oligonucleosomal DNA fragments characteristic of apoptosis, as assayed by gel electrophoresis and enzyme-linked immunosorbent assay. Inhibition was detected 2 h after infection and increased over time. Importantly, HSV-1-infected cells were resistant to apoptosis induced by antigen-specific CD4+ CTL, despite the fact that CTL recognition and degranulation in response to infected targets remained intact. Unlike HSV-1, HSV-2 (strains 333 and HG52) did not inhibit DNA fragmentation. In contrast to the...Continue Reading

References

Dec 15, 1991·Journal of Immunological Methods·A SuhrbierD J Moss
Dec 15, 1991·Journal of Immunological Methods·P Matzinger
Apr 7, 1995·Cell·G Berke
Sep 29, 1995·The Journal of Biological Chemistry·M TewariV M Dixit
Nov 1, 1995·The Journal of Experimental Medicine·B VerhovenP Williamson
Sep 21, 1995·The New England Journal of Medicine·A WaldL Corey
Mar 31, 1995·Journal of Molecular Biology·D J McGeochE A Telford
Mar 1, 1996·The Journal of Experimental Medicine·W W KwokD M Koelle
Jun 1, 1996·Journal of Leukocyte Biology·E M Bruckheimer, A J Schroit
Jan 1, 1996·Advances in Experimental Medicine and Biology·R A SchlegelP Williamson
Jan 1, 1996·Advances in Experimental Medicine and Biology·S J MartinD R Green
Mar 1, 1997·Journal of Virology·J G Teodoro, P E Branton
Apr 1, 1997·Seminars in Immunology·C T Pham, T J Ley
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·R LeopardiB Roizman
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·C M PosavadL Corey

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Citations

May 9, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S Barcy, L Corey
Sep 10, 2003·International Reviews of Immunology·Martine Aubert, Keith R Jerome
May 14, 2004·Journal of Virology·Trine H MogensenSøren R Paludan
Oct 30, 2004·Current Eye Research·David H MilesSreedharan Athmanathan
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yangming XiaoGuangming Zhong
Jul 8, 2003·The Journal of Biological Chemistry·M Antonietta MediciAntonio Mastino
Dec 24, 2003·International Reviews of Immunology·Margot L GoodkinJohn A Blaho
Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K R JeromeL Corey
Nov 24, 2005·Hematology·Gritta Janka, Udo zur Stadt
Aug 18, 2000·Immunopharmacology and Immunotoxicology·A PratelliC Buonavoglia
Dec 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Derek D SloanKeith R Jerome
Jan 15, 2003·Clinical Microbiology Reviews·Clinton Jones
Jan 17, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Paolo G Arduino, Stephen R Porter
Apr 3, 2009·Journal of Virology·Martine AubertKeith R Jerome
Jan 19, 2002·Journal of Virology·Alexander R MoiseWilfred A Jefferies
Dec 17, 2003·British Journal of Haematology·Gritta E Janka, E M Schneider
Sep 13, 2013·Annual Review of Microbiology·Bernard Roizman, Richard J Whitley
Aug 6, 2003·Gene Therapy·M Aubert, J A Blaho
Jun 14, 2003·Journal of Virology·Margot L GoodkinJohn A Blaho
May 26, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Elise R Morton, John A Blaho
Oct 6, 2020·Frontiers in Microbiology·Estefanía CastilloPablo A González
Nov 24, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·C S MillerR J Jacob
May 8, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephen F StanzialeYuman Fong

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