PMID: 8971002Dec 1, 1996Paper

Herpes simplex virus type 2 inhibition of Fas ligand expression

Journal of Virology
S SiegD Kaplan

Abstract

Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are common human pathogens. In this report we demonstrate the capacity of HSV-2, but not HSV-1, to inhibit the activity and cell surface expression of Fas ligand, an important molecule involved in T-cell apoptosis and cell-mediated cytotoxicity. Cells infected with HSV-2 retained Fas ligand intracellularly instead of expressing it on the cell surface. Addition of anti-Fas antibodies markedly inhibited HSV-2 viral production, suggesting that the capacity of the virus to regulate Fas ligand expression, and thereby programmed cell death, may represent a powerful mechanism for the virus to enhance viral replication.

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Citations

Nov 5, 1999·Annual Review of Microbiology·A RoulstonP E Branton
Apr 1, 1997·Immunological Reviews·T A Ferguson, T S Griffith
May 24, 2005·Apoptosis : an International Journal on Programmed Cell Death·P ClarkeK L Tyler
Dec 1, 2009·Viruses·Jesper MelchjorsenSøren R Paludan
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·S SiegD Kaplan
Jun 12, 2004·Proceedings of the National Academy of Sciences of the United States of America·Luca Benetti, Bernard Roizman
Oct 29, 2010·Journal of Medical Virology·Koushik ChatterjeeAnna-Lise Williamson
Jul 28, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·O Dakovic RodeJ Begovac
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J BertinJ I Cohen
Aug 10, 2000·Journal of Virology·P ClarkeK L Tyler

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