Herpes simplex virus vectors elicit durable immune responses in the presence of preexisting host immunity

Journal of Virology
M A Brockman, David M Knipe

Abstract

Herpes simplex virus (HSV) recombinants are being developed as vaccine vectors for the expression of heterologous antigens. There is concern, however, that preexisting HSV immunity may decrease their effectiveness. We have addressed this issue in an animal model. Immunized mice were inoculated with a replication-defective HSV-1 vector that expressed the Escherichia coli beta-galactosidase protein as a model antigen. We assessed vector efficacy by analyzing the immunoglobulin G (IgG) antibody response and cellular proliferative response directed against beta-galactosidase. We report that the ability of the vector to induce antibody or proliferative responses was not diminished by preexisting immunity to HSV. Of further note, the anti-HSV and anti-beta-galactosidase IgG responses following vector administration were extremely durable in both immunized and naive mice. These results indicate that the ability of a replication-defective HSV-derived vaccine vector to elicit long-lived immune responses in mice is not impaired by prior HSV exposure.

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Citations

Dec 10, 2009·Pharmaceutical Research·Paul E LundChava Kimchi-Sarfaty
Jan 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Evelyn A Kurt-JonesRobert W Finberg
Aug 2, 2007·Expert Opinion on Biological Therapy·Delphine CuchetAlberto L Epstein
Jun 7, 2005·Expert Opinion on Biological Therapy·Luisa BarzonGiorgio Palù
Nov 12, 2005·Current Eye Research·David M Koelle, Homayon Ghiasi
Oct 13, 2006·Advanced Drug Delivery Reviews·Richard HarropMiles W Carroll
Nov 24, 2012·Microbiology·Manvendra SaxenaPeter M Smooker
Jun 30, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Pedro R Lowenstein
Jun 24, 2009·Memórias do Instituto Oswaldo Cruz·Alberto Luis Epstein
Aug 14, 2015·Journal of Virology·David C BloomRichard Voellmy
Dec 18, 2007·The Journal of Gene Medicine·Anna BaoutinaKerry R Emslie
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Admar VerschoorMichael C Carroll
Jul 3, 2019·Reviews in Medical Virology·Rana Jahanban-EsfahlanSamira Shirooie
Aug 22, 2021·Proceedings of the National Academy of Sciences of the United States of America·Katherine KaugarsWilliam R Jacobs

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