PMID: 8946013Nov 13, 1996Paper

Herpes virus saimiri transformation of T cells in CD3 gamma immunodeficiency: phenotypic and functional characterization

Journal of Immunological Methods
C Rodríguez-GallegoA Arnaiz-Villena

Abstract

The characterization of T cell immunodeficiencies could in part be supported by using stable cell lines in which biochemical and molecular studies of the defect could be carried out thereby omitting frequent bleeding of patients. First attempts to obtain such cell lines included HTLV-I transformation and exogenous IL-2 administration, but both models have important disadvantages. Recently, a virus isolated from the squirrel monkey, Herpes virus saimiri (HVS), has been reported to have the ability to transform T cells. A stable IL-2-dependent HVS-transformed T cell line from a CD3 gamma deficient patient has been obtained; and this cell line displays both the phenotypic and the functional characteristics of the patient's lymphocytes. Moreover, the line down-modulates TCR/CD3 surface expression upon CD3 engagement, as do the patient's lymphocytes, showing that CD3 gamma and its phosphorylation are not necessary for TCR/CD3 internalization. In addition, the abnormal staining pattern of different anti-TCR/CD3 monoclonal antibodies is preserved in the HVS-patient line. Since HVS is capable of transforming CD3 gamma- T cells, the CD3 gamma chain does not seem to be involved in the HVS receptor process. The fact that it is not possibl...Continue Reading

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Citations

Feb 16, 2000·Journal of Neuroimmunology·E Meinl, R Hohlfeld
Apr 21, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H Fickenscher, B Fleckenstein
Jan 4, 2001·Clinical and Diagnostic Laboratory Immunology·L M AllendeA Arnaiz-Villena
Apr 12, 2001·Clinical and Experimental Immunology·M A García-PérezA Arnaiz-Villena
Apr 16, 2003·British Journal of Haematology·Nobuyuki YoshidaMasaki Yasukawa
Jul 19, 2011·Cellular Immunology·Jesús ReinéMaría J Recio
Feb 25, 2005·Journal of Leukocyte Biology·José M Martín-FernándezJosé R Regueiro
Nov 2, 2016·Current Protocols in Immunology·Rubén Martínez-BarricarteJean-Laurent Casanova
Sep 25, 2004·Journal of Cellular Physiology·Alexander Y Tsygankov
Jun 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pilar S TorresJosé R Regueiro

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