Herpesviral Fcgamma receptors: culprits attenuating antiviral IgG?

International Immunopharmacology
Matthias BudtHartmut Hengel

Abstract

Production of IgG in response to virus infection is central to antiviral immune effector functions and a hallmark of B cell memory. Antiviral antibodies (Abs) recognising viral glycoproteins or protein antigen displayed on the surface of virions or virus-infected cells are crucial in rendering the virus noninfectious and in eliminating viruses or infected cells, either acting alone or in conjunction with complement. In many instances, passive transfer of Abs is sufficient to protect from viral infection. Herpesviruses (HV) are equipped with a large array of immunomodulatory functions which increase the efficiency of infection by dampening the antiviral immunity. Members of the alpha- and beta-subfamily of the Herpesviridae are distinct in encoding transmembrane glycoproteins which selectively bind IgG via its Fc domain. The Fc-binding proteins constitute viral Fcgamma receptors (vFcgammaRs) which are expressed on the cell surface of infected cells. Moreover, vFcgammaRs are abundantly incorporated into the envelope of virions. Despite their molecular and structural heterogeneity, the vFcgammaRs generally interfere with IgG-mediated effector functions like antibody (Ab)-dependent cellular cytolysis, complement activation and neut...Continue Reading

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Citations

Jan 15, 2008·Immunologic Research·Steven J BurgessJohn E Coligan
Jul 13, 2006·The Journal of Experimental Medicine·Tihana LenacStipan Jonjic
Jan 25, 2008·Journal of Virology·Elizabeth R SpraguePamela J Bjorkman
May 17, 2014·PLoS Pathogens·Eugenia Corrales-AguilarHartmut Hengel
Oct 8, 2014·Seminars in Immunopathology·Eugenia Corrales-AguilarHartmut Hengel
Jan 7, 2017·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·N ClementiM Clementi
Feb 11, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcel Costa-GarciaAura Muntasell

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Methods Mentioned

BETA
fluorescence resonance

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