Herpesvirus-6 encephalitis complicated by Wernicke-Korsakoff syndrome in a pediatric recipient of unrelated cord blood transplantation

Journal of Pediatric Hematology/oncology
E CarvajalV Castel

Abstract

A 10-year-old girl with M2 acute myeloid leukemia underwent an unrelated cord blood transplantation in refractory first relapse. On day +13, after 48 hours with fever, she showed a measles-like rash, and on day +15, she began experiencing neurologic symptoms (headache, tremors, weakness, nystagmus, mild confusion, speaking, taste, and behavior disturbances, and focal seizures). She also had amnesia for recent events with disability to learn, mimicking Wernicke-Korsakoff syndrome. Computed tomography of the brain and cerebrospinal fluid (CSF) and electroencephalogram were nonspecific. We found human herpesvirus 6 (HHV-6) DNA in CSF and cytomegalovirus in bronchoalveolar lavage using polymerase chain reaction techniques. Treatment with ganciclovir and foscarnet was effective, with total resolution of symptoms.

References

Jan 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K K Knox, D R Carrigan
Apr 1, 1997·Archives of Disease in Childhood·D W WebbE E Thomas
May 1, 1997·Archives of Disease in Childhood·T J David
Aug 28, 1998·Bone Marrow Transplantation·A BosiP Rossi Ferrini

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Citations

Aug 7, 2007·Neuropsychological Rehabilitation·Laura Hokkanen, Jyrki Launes
Oct 14, 2008·Radiology·James M ProvenzaleLeonard E White
Sep 18, 2008·European Journal of Pediatrics·Masashi NishidaKenji Hamaoka
Dec 17, 2009·Pediatric Neurology·James M ProvenzaleLeonard E White
Mar 21, 2007·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Todd E PetersRichard L Levine
Feb 6, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Danielle M Zerr
Feb 27, 2004·British Journal of Haematology·Tetsushi Yoshikawa

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