Herpetic eye disease study: lessons learned

Current Opinion in Ophthalmology
Tanja KalezicP A Asbell

Abstract

Ophthalmic herpes simplex virus (HSV) of the anterior segment is responsible for a range of corneal complications such as scarring, thinning, neovascularization, and severe loss of vision. This review provides current guidelines for treating anterior segment disease related to HSV. We first review findings from the Herpetic Eye Disease Study (HEDS) clinical trials, and then review new topical and antiviral therapies developed since the HEDS studies. The development of vaccines to prevent recurrent episodes of herpetic infection is briefly reviewed. New corneal surgical procedures, developed since HEDS, may put patients at risk for ocular HSV disease: cross-linking and excimer refractive surgery. HEDS established the standard of HSV ocular therapy and is still valid today. However, newer antivirals may provide easier compliance with improved bioavailability, efficacy, dosage, and tolerability. Further research is needed to prevent latency of HSV, decrease recurrences, and more effectively treat necrotizing keratitis associated with HSV.

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Citations

Nov 18, 2018·F1000Research·Richard Whitley, Joel Baines
Apr 26, 2019·Human Gene Therapy·Enzo Di IorioGiorgio Palù
Feb 23, 2020·Pharmaceutics·Florina-Daniela CojocaruCosmin-Teodor Mihai
Sep 10, 2020·Polymers·Angela Varela-GarciaCarmen Alvarez-Lorenzo
Nov 23, 2019·International Ophthalmology·Elif ErdemFügen Yarkın
Nov 25, 2020·Indian Journal of Ophthalmology·Shilpa DasSriram Annavajjhala
Mar 11, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Sana ArshadNicole A Carnt
Feb 6, 2019·Archivos de la Sociedad Española de Oftalmología·F Pérez-BartoloméF J Muñoz Negrete

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