HERV-K(HML-2) rec and np9 transcripts not restricted to disease but present in many normal human tissues

Mobile DNA
Katja SchmittJens Mayer

Abstract

Human endogenous retroviruses of the HERV-K(HML-2) group have been associated with the development of tumor diseases. Various HERV-K(HML-2) loci encode retrovirus-like proteins, and expression of such proteins is upregulated in certain tumor types. HERV-K(HML-2)-encoded Rec and Np9 proteins interact with functionally important cellular proteins and may contribute to tumor development. Though, the biological role of HERV-K(HML-2) transcription and encoded proteins in health and disease is less understood. We therefore investigated transcription specifically of HERV-K(HML-2) rec and np9 mRNAs in a panel of normal human tissues. We obtained evidence for rec and np9 mRNA being present in all examined 16 normal tissue types. A total of 18 different HERV-K(HML-2) loci were identified as generating rec or np9 mRNA, among them loci not present in the human reference genome and several of the loci harboring open reading frames for Rec or Np9 proteins. Our analysis identified additional alternative splicing events of HERV-K(HML-2) transcripts, some of them encoding variant Rec/Np9 proteins. We also identified a second HERV-K(HML-2) locus formed by L1-mediated retrotransposition that is likewise transcribed in various human tissues. HERV-...Continue Reading

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Citations

Jan 29, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Kirsten HankeNorbert Bannert
Sep 15, 2015·Journal of Proteome Research·Elspeth A BrufordJennifer Harrow
Mar 1, 2018·Frontiers in Microbiology·Norbert BannertOliver Hohn
Oct 20, 2017·Journal of Virology·Meagan MontesionJohn M Coffin
Oct 16, 2018·Critical Reviews in Microbiology·Marta Garcia-MontojoAvindra Nath
Sep 13, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·George Kassiotis, Jonathan P Stoye
Dec 6, 2019·International Journal of Molecular Sciences·Emanuela BalestrieriPaola Sinibaldi Vallebona
Mar 30, 2018·Frontiers in Microbiology·Nicole Grandi, Enzo Tramontano
Mar 24, 2016·Proceedings of the National Academy of Sciences of the United States of America·Julia Halo WildschutteJohn M Coffin
Jul 27, 2018·Molecular Neurobiology·Gerwyn MorrisBasant K Puri
Jun 1, 2021·Frontiers in Oncology·Eoin DervanSharon A Glynn

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Datasets Mentioned

BETA
LN624403
LN680257
PRJEB8273

Methods Mentioned

BETA
PCR
transgenic
electrophoresis
RNA-seq

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