Hes1 and Hes5 are required for differentiation of pituicytes and formation of the neurohypophysis in pituitary development

Brain Research
Masanori GotoSusumu Miyamoto

Abstract

The pituitary gland is a critical endocrine organ regulating diverse physiological functions, including homeostasis, metabolism, reproduction, and growth. It is composed of two distinct entities: the adenohypophysis, including the anterior and intermediate lobes, and the neurohypophysis known as the posterior lobe. The neurohypophysis is composed of pituicytes (glial cells) and axons projected from hypothalamic neurons. The adenohypophysis derives from Rathke's pouch, whereas the neurohypophysis derives from the infundibulum, an evagination of the ventral diencephalon. Molecular mechanisms of adenohypophysis development are much better understood, but little is known about mechanisms that regulate neurohypophysis development. Hes genes, known as Notch effectors, play a crucial role in specifying cellular fates during the development of various tissues and organs. Here, we report that the ventral diencephalon fails to evaginate resulting in complete loss of the posterior pituitary lobe in Hes1(-/-); Hes5(+/-) mutant embryos. In these mutant mice, progenitor cells are differentiated into neurons at the expense of pituicytes in the ventral diencephalon. In the developing neurohypophysis, the proliferative zone is located at the ba...Continue Reading

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Citations

May 10, 2012·PloS One·Jörg WaldhausHubert Löwenheim
Jun 20, 2014·PLoS Computational Biology·Jerry S ChenJoseph M Mahaffy
Aug 18, 2016·Molecular and Cellular Endocrinology·Karine Rizzoti, Robin Lovell-Badge
Sep 22, 2016·Molecular and Cellular Endocrinology·Leonard Y M CheungMaría Inés Pérez-Millán
Jan 10, 2018·Genes·Vanessa ZammitDuncan Ayers
Jun 27, 2018·Journal of Molecular Endocrinology·Mitsushige AndoSusumu Miyamoto
May 6, 2019·Journal of Neuroendocrinology·Travis FuMarysia Placzek
May 12, 2018·International Journal of Molecular Medicine·Wendong RuanYan Hao
Oct 12, 2018·Journal of Molecular Endocrinology·Mitsushige AndoSusumu Miyamoto

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