Hes5.9 Coordinate FGF and Notch Signaling to Modulate Gastrulation via Regulating Cell Fate Specification and Cell Migration in Xenopus tropicalis.

Genes
Xiao HuangPeichao Chen

Abstract

Gastrulation drives the establishment of three germ layers and embryonic axes during frog embryonic development. Mesodermal cell fate specification and morphogenetic movements are vital factors coordinating gastrulation, which are regulated by numerous signaling pathways, such as the Wnt (Wingless/Integrated), Notch, and FGF (Fibroblast growth factor) pathways. However, the coordination of the Notch and FGF signaling pathways during gastrulation remains unclear. We identified a novel helix-loop-helix DNA binding domain gene (Hes5.9), which was regulated by the FGF and Notch signaling pathways during gastrulation. Furthermore, gain- and loss-of-function of Hes5.9 led to defective cell migration and disturbed the expression patterns of mesodermal and endodermal marker genes, thus interfering with gastrulation. Collectively, these results suggest that Hes5.9 plays a crucial role in cell fate decisions and cell migration during gastrulation, which is modulated by the FGF and Notch signaling pathways.

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Citations

Feb 10, 2021·Journal of the Royal Society, Interface·Supriya BajpaiMandar M Inamdar

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Methods Mentioned

BETA
antisense oligonucleotides
electrophoresis
PCR
Reverse Transcription PCR
RNA-Seq
genetic interference

Software Mentioned

DEGSeq R
DNAMAN
GOseq R package
Ensemble
JASPAR
Ensembl
HTSeq
KOBAS

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