Hesperetin induces melanin production in adult human epidermal melanocytes

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Iris UsachJosé-Esteban Peris

Abstract

One of the major sources of flavonoids for humans are citrus fruits, hesperidin being the predominant flavonoid. Hesperetin (HSP), the aglycon of hesperidin, has been reported to provide health benefits such as antioxidant, anti-inflammatory and anticarcinogenic effects. However, the effect of HSP on skin pigmentation is not clear. Some authors have found that HSP induces melanogenesis in murine B16-F10 melanoma cells, which, if extrapolated to in vivo conditions, might protect skin against photodamage. Since the effect of HSP on normal melanocytes could be different to that observed on melanoma cells, the described effect of HSP on murine melanoma cells has been compared to the effect obtained using normal human melanocytes. HSP concentrations of 25 and 50 µM induced melanin synthesis and tyrosinase activity in human melanocytes in a concentration-dependent manner. Compared to control melanocytes, 25 µM HSP increased melanin production and tyrosinase activity 1.4-fold (p < 0.01) and 1.1-fold (p < 0.01), respectively, and the corresponding increases in the case of 50 µM HSP were 1.9-fold (p < 0.001) and 1.3-fold (p < 0.001). Therefore, HSP could be considered a valuable photoprotective substance if its capacity to increase mela...Continue Reading

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Citations

Feb 13, 2016·Molecular Nutrition & Food Research·Feng Liu-Smith, Frank L Meyskens
May 8, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Mao-Qiang ManPeter M Elias
Sep 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jing TengMingfu Wang
Sep 3, 2019·Biological & Pharmaceutical Bulletin·Nobuhiko TaguchiTakahiro Kunisada
May 18, 2021·Pigment Cell & Melanoma Research·Avni Nautiyal, Sarika Wairkar

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