Dec 17, 2014

Hesperidin ameliorates behavioral impairments and neuropathology of transgenic APP/PS1 mice

Behavioural Brain Research
Chaoyun LiZhi-Yuan Zhang

Abstract

In addition to cognitive impairments, deficits in non-cognitive behaviors are also common neurological sequelae in Alzheimer's disease and its animal models. Hesperidin, a flavanone glycoside found abundantly in citrus fruits, was orally given (100 mg/kg body weight) to 5-month-old transgenic APP/PS1 mice, a mouse model of cerebral amyloidosis for Alzheimer's disease. After a relatively short-term treatment of 10 days, hesperidin significantly restored deficits in non-cognitive nesting ability and social interaction. Further immunohistochemical analysis showed significantly attenuated β-amyloid deposition, plaque associated APP expression, microglial activation and TGF-β immunoreactivity in brains of APP/PS1 mice, which suggests that ameliorated behavioral impairments might be attributable to reduced Aβ deposition and attenuated neuro-inflammatory reaction. Additionally, efficient anti-inflammatory effects of hesperidin were confirmed in vitro. Our findings suggest that hesperidin might be a potential candidate for the treatment of AD or even other neurodegenerative diseases.

  • References34
  • Citations11

Mentioned in this Paper

ISYNA1 gene
Familial Alzheimer Disease (FAD)
Immunomodulators
Transforming Growth Factor beta
Cortex Bone Disorders
Adrenal Cortex Diseases
APP protein, human
Glial Fibrillary Acidic Protein
Fast blue BB salt stain
Actins

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