Hesperidin ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting HMGB1 release

International Immunopharmacology
Xin-xin LiuBo-xu Ren

Abstract

Hesperidin (HDN), a flavanone glycoside, possesses anti-inflammatory properties and has been suggested to be able to modulate the lipopolysaccharide (LPS)-induced acute lung injury (ALI). High-mobility group box 1 (HMGB1) serves as an inflammatory cytokine when released extracellularly and is involved in the pathogenesis of diverse inflammatory disorders. The current study aimed to investigate the involvement of HMGB1 in HDN-induced immunoregulation of ALI. ALI in male BALB/c mice was induced by intranasal administration of LPS (0.5mg/kg). HDN (500mg/kg) was administered intragastrically 10days prior to LPS exposure. HDN significantly protected animals from LPS-induced ALI as evidenced by decreased elevation of the lung wet to dry weight ratio, total cells, neutrophils, macrophages, and myeloperoxidase (MPO) activity, associated with reduced lung histological damage. In the meantime, HDN pretreatment markedly inhibited the production of pro-inflammatory cytokines and chemokine, including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1). Furthermore, HDN pretreatment dramatically inhibited the infiltration of macrophages and suppressed the expression and release of HMGB1 in viv...Continue Reading

References

Jul 10, 1999·Science·H WangK J Tracey
Aug 17, 2000·The New England Journal of Medicine
Dec 18, 2001·Phytotherapy Research : PTR·A GargA K Singla
May 11, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ulrich A MausJürgen Lohmeyer
Jul 12, 2002·Nature·Paola ScaffidiMarco E Bianchi
Nov 19, 2003·Scandinavian Journal of Infectious Diseases·Ulf Andersson, Kevin J Tracey
May 11, 2004·Biological & Pharmaceutical Bulletin·Kiichiro KawaguchiYoshio Kumazawa
Sep 18, 2004·American Journal of Respiratory and Critical Care Medicine·Hiroshi UenoAkitoshi Ishizaka
Apr 2, 2005·Nature Reviews. Immunology·Michael T Lotze, Kevin J Tracey
Aug 2, 2005·Nature Reviews. Drug Discovery·Luis Ulloa
Oct 21, 2005·The New England Journal of Medicine·Gordon D RubenfeldLeonard D Hudson
Aug 16, 2006·Seminars in Respiratory and Critical Care Medicine·Lorraine B Ware
Sep 7, 2006·The Journal of Clinical Investigation·Tohru Minamino, Issei Komuro
Jul 3, 2008·Journal of Agricultural and Food Chemistry·O Benavente-García, J Castillo
Jul 29, 2010·Respiration; International Review of Thoracic Diseases·Yun Feng NiTao Jiang
Sep 18, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Quan GongFei-li Gong
Dec 7, 2010·Expert Review of Respiratory Medicine·Hong ChenXiangdong Wang
Jun 7, 2011·Postgraduate Medical Journal·A DushianthanR Cusack
Oct 16, 2012·European Journal of Pharmacology·Chao WangQuan Gong

❮ Previous
Next ❯

Citations

Sep 23, 2016·Clinical and Experimental Hypertension : CHE·Xin ZhaoQingjun Gao
Jul 20, 2016·International Journal of Molecular Medicine·Jae-Won LeeKyung-Seop Ahn
Jan 15, 2020·Current Neuropharmacology·Miryam Nava Catorce, Goar Gevorkian
Sep 3, 2019·Biochemical and Biophysical Research Communications·Yanjun ZengPinhua Pan
Oct 3, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yu-Qiong HeWan-Sheng Chen
Jan 10, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zihe DingZunpeng Shu
Jul 15, 2021·BioMed Research International·Wen-Ying YuChen-Huan Yu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Cardiac Glycosides

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit na+/k+-atpase. Discover the latest research on cardiac glycosides heres.