Hesperidin Loaded on Gold Nanoparticles as a Drug Delivery System for a Successful Biocompatible, Anti-Cancer, Anti-Inflammatory and Phagocytosis Inducer Model.

Scientific Reports
Ghassan M SulaimanYougasphree Naidoo

Abstract

Hesperidin is a flavonoid glycoside with proven therapeutic activities for various diseases, including cancer. However, its poor solubility and bioavailability render it only slightly absorbed, requiring a delivery system to reach its therapeutic target. Hesperidin loaded on gold nanoparticles (Hsp-AuNPs) was prepared by a chemical synthesis method. Various characterization techniques such as UV-VIS spectroscopy, FTIR, XRD, FESEM, TEM and EDX, Zeta potential analysis, particle size analysis, were used to confirm the synthesis of Hsp-AuNPs. The cytotoxic effect of Hsp-AuNPs on human breast cancer cell line (MDA-MB-231) was assessed using MTT and crystal violet assays. The results revealed significant decrease in proliferation and inhibition of growth of the treated cells when compared with human normal breast epithelial cell line (HBL-100). Determination of apoptosis by fluorescence microscope was also performed using acridine orange-propidium iodide dual staining assay. The in vivo study was designed to evaluate the toxicity of Hsp-AuNPs in mice. The levels of hepatic and kidney functionality markers were assessed. No significant statistical differences were found for the tested indicators. Histological images of liver, spleen,...Continue Reading

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Citations

Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Ivan V ZelepukinSergey M Deyev
Feb 5, 2021·International Journal of Nanomedicine·Xuan ShaJingjing Li
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Dec 10, 2021·Nanomedicine·Tânia Ferreira-GonçalvesCatarina P Reis

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Methods Mentioned

BETA
X-ray
ELISA
surface plasmon resonance
infrared spectroscopy
scanning electron microscopy
transmission electron microscopy
fluorescence microscopy

Software Mentioned

SPSS
MIRA

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