Abstract
Gout arthritis is a painful inflammatory disease induced by monosodium urate (MSU) crystals. We evaluate the therapeutic potential of the flavonoid hesperidin methylchalcone (HMC) in a mouse model of gout arthritis induced by intra-articular injection of MSU (100 μg/10 μL). Orally given HMC (3-30 mg/kg, 100 μL) reduced in a dose-dependent manner the MSU-induced hyperalgesia (44%, p < 0.05), edema (54%, p < 0.05), and leukocyte infiltration (70%, p < 0.05). HMC (30 mg/kg) inhibited MSU-induced infiltration of LysM-eGFP+ cells (81%, p < 0.05), synovitis (76%, p < 0.05), and oxidative stress (increased GSH, FRAP, and ABTS by 62, 78, and 73%, respectively; reduced O2- and NO by 89 and 48%, p < 0.05) and modulated cytokine production (reduced IL-1β, TNF-α, IL-6, and IL-10 by 35, 72, 37, and 46%, respectively, and increased TGF-β by 90%, p < 0.05). HMC also inhibited MSU-induced NF-κB activation (41%, p < 0.05), gp91phox (66%, p < 0.05) and NLRP3 inflammasome components mRNA expression in vivo (72, 77, 71, and 73% for NLRP3, ASC, pro-caspase-1, and pro-IL-1 β, respectively, p < 0.05), and induced Nrf2/HO-1 mRNA expression (3.9- and 5.1-fold increase, respectively, p < 0.05). HMC (30, 100, and 300 μM) did not inhibit IL-1β secretion b...Continue Reading
References
Nov 1, 1992·Annals of the Rheumatic Diseases·A J FarrellS Moncada
Apr 1, 1991·The Journal of Clinical Investigation·F S di GiovineG W Duff
Nov 1, 1989·Arthritis and Rheumatism·P A GuerneM Lotz
May 20, 1998·Arthritis and Rheumatism·R TerkeltaubW Boisvert
Dec 22, 1999·Biochemical Pharmacology·A Bowie, L A O'Neill
Jan 6, 2000·Transgenic Research·B E ClausenI Förster
Dec 18, 2001·Phytotherapy Research : PTR·A GargA K Singla
Feb 28, 2004·The Journal of Pharmacology and Experimental Therapeutics·Zhi-Qiang WangDaniela Salvemini
Apr 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maritza JaramilloMartin Olivier
Nov 30, 2004·Nitric Oxide : Biology and Chemistry·Linda ChenShu-Huei Tsai
Jan 13, 2006·Nature·Fabio MartinonJürg Tschopp
Jul 6, 2006·Arthritis Research & Therapy·Bruce N Cronstein, Robert Terkeltaub
Aug 4, 2006·The Journal of Clinical Investigation·Fabio Martinon, Laurie H Glimcher
Apr 12, 2007·International Anesthesiology Clinics·Jun-Ming Zhang, Jianxiong An
Oct 26, 2007·Molecular Pharmaceutics·Thomas Walle
Mar 29, 2008·European Journal of Pain : EJP·Thiago M CunhaFernando Q Cunha
Jun 19, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ellen Niederberger, Gerd Geisslinger
Jul 3, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Franz G BauernfeindEicke Latz
Jul 14, 2009·Annals of the Rheumatic Diseases·A Elisabeth HakHyon K Choi
Jul 22, 2009·Phlebology·J J GuexC Taïeb
Feb 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hidenori HattoriHongbo R Luo
Mar 5, 2010·European Journal of Immunology·Fabio Martinon
Mar 23, 2010·Cell·Kate Schroder, Jurg Tschopp
May 6, 2010·Arthritis Research & Therapy·Nathalie Busso, Alexander So
Jun 3, 2010·The Journal of Clinical Investigation·Alexander So, Bernard Thorens
Feb 4, 2011·The New England Journal of Medicine·Tuhina Neogi
Jul 30, 2011·Arthritis and Rheumatism·Yanyan ZhuHyon K Choi
Aug 31, 2011·Circulation·Philip WenzelThomas Münzel
Sep 29, 2011·Arthritis and Rheumatism·Flávio A AmaralMauro M Teixeira
Mar 21, 2012·Critical Reviews in Immunology·Shankar Subramanian Iyer, Gehong Cheng
Sep 5, 2012·Nature Reviews. Rheumatology·Kenneth L RockJiann-Jyh Lai
Sep 18, 2012·Immunopharmacology and Immunotoxicology·Rong LiJun Li
Dec 12, 2012·Biochemical Pharmacology·Holly K BryanB Kevin Park
Jun 12, 2013·Nature Medicine·Djalma S Lima-JuniorDario S Zamboni
Aug 1, 2013·Journal of Leukocyte Biology·Stephan PaschkeEldad Ben-Chetrit
Jan 27, 2015·Chemico-biological Interactions·Felipe A Pinho-RibeiroWaldiceu A Verri
Apr 10, 2015·Clinical Rheumatology·Yessica Zamudio-CuevasAlberto López-Reyes
Apr 29, 2015·Arthritis & Rheumatology·Angélica T VieiraCharles R Mackay
Jul 8, 2015·Nature Reviews. Rheumatology·Chang-Fu KuoMichael Doherty
Aug 8, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Karla G G SerafimWaldiceu A Verri
Mar 30, 2016·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Renata M MartinezRubia Casagrande
Apr 6, 2016·PloS One·Marília F ManchopeWaldiceu A Verri
Jun 9, 2016·European Journal of Pharmacology·Chitra Dhanasekar, Mahaboobkhan Rasool
Jun 15, 2016·International Journal of Molecular Sciences·Nayely Leyva-LópezJ Basilio Heredia
Feb 6, 2017·Scientific Reports·Talita P DomicianoKenichi Shimada
May 17, 2017·Inflammopharmacology·Kenji W Ruiz-MiyazawaWaldiceu A Verri
Citations
Mar 1, 2019·Molecular Nutrition & Food Research·Kun GuoJieshou Li
Apr 22, 2019·Biomolecules & Therapeutics·Hyun LimHyun Pyo Kim
Jun 20, 2019·Food & Function·Yue ZhangFeng Chen
Mar 14, 2020·Journal of Receptor and Signal Transduction Research·Shuyun WangLiping Liu
Feb 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Camila R FerrazWaldiceu A Verri
Jan 29, 2019·Frontiers in Pharmacology·Larissa Staurengo-FerrariWaldiceu A Verri
Oct 20, 2018·Frontiers in Pharmacology·Larissa Staurengo-FerrariWaldiceu A Verri
Feb 13, 2020·Inflammopharmacology·Fernanda S Rasquel-OliveiraWaldiceu A Verri
Apr 10, 2020·Current Pharmaceutical Design·Tarique HussainDildar H Kalhoro
Nov 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sarmistha SahaLuciano Saso
Jan 19, 2021·Journal of Ethnopharmacology·Le ShiTao Liang
Nov 11, 2020·Chemico-biological Interactions·Carla F S GuazelliWaldiceu A Verri
Jan 29, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Jieru HanDeyou Jiang
Jan 10, 2021·International Journal of Molecular Sciences·Young-Su Yi
Mar 5, 2021·International Journal of Biological Macromolecules·Camila R FerrazWaldiceu A Verri
Mar 12, 2021·Expert Review of Clinical Pharmacology·Melford Chuka EgbujorLuciano Saso
May 11, 2021·Frontiers in Pharmacology·Wan-Yang LiGuo-Feng Ren
Nov 13, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Eloísa Portugal Barros Silva Soares de SouzaAdriano Antunes de Souza Araújo
Oct 22, 2021·Journal of Agricultural and Food Chemistry·Ze-Rui SunJun Sheng