Hesperidin supplementation modulates inflammatory responses following myocardial infarction

Journal of the American College of Nutrition
Fatemeh HaidariE Shirbeigi

Abstract

A growing number of studies have suggested a crucial role for a variety of inflammatory mediators in myocardial infarction. Recently, several flavonoids have been shown to have cardioprotective and anti-inflammatory properties. Therefore, the aim of this study was to investigate the effect of hesperidin-a common constituent of citrus fruits-on the serum levels of inflammatory markers and adipocytocines in patients with myocardial infarction. Seventy-five patients with myocardial infarction were participated in this randomized, double-blind controlled clinical trial and were assigned to 2 intervention and control groups. Subjects consumed 600 mg/d pure hesperidin supplement and placebo in the intervention and control groups, respectively, for 4 weeks. Serum concentrations of inflammatory markers and adipocytocines were measured at baseline and at the end of the intervention. Consumption of 600 mg/day hesperidin significantly decreased the serum levels of E-selectin and increased adiponectin and high-density lipoprotein cholesterol (HDL-C) concentrations in patients with myocardial infarction. The improvement in other inflammatory markers, such as interleukin (IL)-6, high-sensitivity C-reactive protein (hs-CRP), leptin, and other...Continue Reading

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Citations

Oct 22, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Kapil SuchalDharamvir Singh Arya
Apr 27, 2017·Journal of the American College of Nutrition·Sergio AmmendolaAnna Scotto d'Abusco
May 13, 2017·BioFactors·Davide BarrecaSeyed Mohammad Nabavi
Sep 4, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Zhanzhong QinLei Zheng
Oct 11, 2019·International Journal of Molecular Sciences·Mohammad Hosein FarzaeiAnupam Bishayee
Apr 30, 2020·Experimental and Therapeutic Medicine·Mahmoud HashemzaeiJafar Shahraki
Jan 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Prachya KongtawelertThanyaluck Phitak
Apr 19, 2020·International Immunopharmacology·Brice Ayissi OwonaPaul Fewou Moundipa

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

Statistical Package for Social Sciences ( SPSS
Nutritionist IV

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