Hesperidin Suppresses Renin-Angiotensin System Mediated NOX2 Over-Expression and Sympathoexcitation in 2K-1C Hypertensive Rats

The American Journal of Chinese Medicine
Chutamas WunpathePoungrat Pakdeechote

Abstract

Hesperidin, a flavonoid derived from citrus fruits, possesses several beneficial effects including anti-oxidation and anti-inflammation. The aim of this study was to investigate the effects of hesperidin on the renin-angiotensin system (RAS) cascade that mediated oxidative stress and sympathoexcitation in two-kidney, one-clipped (2K-1C) hypertensive rats. 2K-1C hypertension was induced in male Sprague-Dawley rats. Hypertensive rats were treated with hesperidin at 20[Formula: see text]mg/kg or 40[Formula: see text]mg/kg or losartan at 10[Formula: see text]mg/kg beginning at three weeks after surgery and then continued for four weeks ([Formula: see text]/group). Hesperidin reduced blood pressure in a dose-dependent manner in hypertensive rats compared to untreated rats ([Formula: see text]). Increased plasma angiotensin converting enzyme (ACE) activity and angiotensin II levels, as well as, upregulated AT1 receptor protein expression in aortic tissues were attenuated in hypertensive rats treated with hesperidin. Hesperidin suppressed oxidative stress markers and NADPH oxidase over-expression, and restored plasma nitric oxide metabolites in 2K-1C rats. This was associated with improvement of the vascular response to acetylcholine ...Continue Reading

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Citations

Apr 30, 2020·Experimental and Therapeutic Medicine·Mahmoud HashemzaeiJafar Shahraki
Apr 10, 2019·Oxidative Medicine and Cellular Longevity·Ayman M MahmoudOmnia E Hussein
Jan 14, 2021·Critical Reviews in Food Science and Nutrition·Yue WangChong-De Sun
Mar 5, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Alena LiskovaPeter Kubatka
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luis Gustavo Saboia PonteFernando Moreira Simabuco
Jul 3, 2021·Pharmaceuticals·Patrícia I C GodinhoVera L M Silva

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