PMID: 2122452Oct 1, 1990Paper

HeT DNA: a family of mosaic repeated sequences specific for heterochromatin in Drosophila melanogaster

Proceedings of the National Academy of Sciences of the United States of America
K ValgeirsdóttirM L Pardue

Abstract

HeT DNA is a complex family of repeated DNA found only in pericentric and telomeric heterochromatin. In contrast to other DNA families that have been specifically associated with heterochromatin, HeT DNA is not principally a family of tandemly repeated elements. Much of the HeT DNA family appears to be a mosaic of several different classes of large sequence elements arranged in a scrambled array; however, some elements of the family can be found in tandem repeats. In spite of the variable order of the different elements in HeT DNA, the sequence homology between different members of each class of element is extremely high, suggesting that the members are evolving in a concerted fashion. Sequence analysis suggests that some elements in the HeT family may make up a novel family of heterochromatin-specific transposable elements and that the mosaic organization of the elements may be produced by retroposition and other mechanisms involved in the transposition of mobile elements. We suggest that such mechanisms may be a general feature for the maintenance of chromosome structure.

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Citations

Dec 1, 1990·Chromosoma·M L Pardue, W Hennig
Apr 1, 1992·Chromosoma·D BroccoliD A Miller
Jan 1, 1995·Virus Genes·J Brosius, H Tiedge
Oct 20, 1998·Biulleten' eksperimental'noĭ biologii i meditsiny·D V BebikhovT A Nikonenko
Feb 1, 1995·Trends in Genetics : TIG·J M Mason, H Biessmann
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·O N DanilevskayaM L Pardue
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·S ZouD F Voytas
Jul 25, 1991·Nucleic Acids Research
May 1, 1995·Insect Molecular Biology·P R EbertH T Nguyen
May 18, 2007·Annual Review of Cell and Developmental Biology·Mary-Lou Pardue
Jan 1, 1994·Genetica·N ParicioR de Frutos
Jan 1, 1992·Genetica·A BuchetonM Simonelig
Feb 1, 1996·Trends in Genetics : TIG·M L PardueK L Traverse
Nov 28, 2000·Annual Review of Genetics·M J McEachernE H Blackburn
Dec 1, 1994·Molecular and Cellular Biology·Y J ZhangJ E Edström
Feb 15, 2003·Genetics·Elizabeth A WinzelerDaniel L Hartl

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