Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors

Bioorganic & Medicinal Chemistry Letters
Jie-Fei ChengAlex M Nadzan

Abstract

A series of heteroaryl-substituted bis-trifluoromethyl carbinols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Some thiazole-based derivatives showed potent in vitro MCD inhibitory activities and significantly increased glucose oxidation rates in isolated working rat hearts.

References

Sep 1, 1979·Archives of Biochemistry and Biophysics·Y S KimA Boos
Jan 1, 1979·The International Journal of Biochemistry·Y S KimA Boos
Mar 1, 1996·European Journal of Endocrinology·M Prentki
Feb 15, 1997·European Journal of Biochemistry·J D McGarry, N F Brown
Aug 7, 1998·The Biochemical Journal·N Alam, E D Saggerson
Jul 27, 1999·American Journal of Human Genetics·D R FitzPatrickJ Christodoulou
Sep 11, 2001·Journal of Neuroscience Research·S SurendranR Matalon
May 29, 2002·Bioorganic & Medicinal Chemistry Letters·Daniel GuayYves Girard
Dec 20, 2002·Angewandte Chemie·Thomas Steiner
Dec 25, 2002·Acta Crystallographica. Section D, Biological Crystallography·Jin-Seok JungByung-Ha Oh
May 9, 2003·The Journal of Biological Chemistry·Shawn WilliamsTimothy M Willson
Oct 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Zhiyuan HuM Daniel Lane
Mar 9, 2004·Protein Expression and Purification·Demin ZhouGuang Yang
Apr 3, 2004·Nature Reviews. Drug Discovery·Neil Ruderman, Marc Prentki
Jun 8, 2004·The Journal of Biological Chemistry·Aneta E ReszkoHenri Brunengraber
Oct 13, 2005·The Journal of Biological Chemistry·Zhiyuan HuM Daniel Lane
Oct 26, 2005·Biochemical Society Transactions·M D LaneA Sidhaye
Nov 1, 2005·Bioorganic & Medicinal Chemistry Letters·Jie-Fei ChengAlex M Nadzan
Jan 3, 2006·Bioorganic & Medicinal Chemistry Letters·Leping LiJulio C Medina

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Citations

Dec 1, 2006·Cardiovascular Drugs and Therapy·Gary D Lopaschuk, William C Stanley
Mar 27, 2015·Antioxidants & Redox Signaling·Miranda M SungJason R B Dyck
Sep 11, 2012·Biochimica Et Biophysica Acta·Natasha Fillmore, Gary D Lopaschuk
May 20, 2008·Journal of Computational Chemistry·Jiazhong LiPaola Gramatica
Jan 20, 2007·Bioorganic & Medicinal Chemistry Letters·David M WallaceAlex M Nadzan

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