Heterocellular molecular contacts in the mammalian stem cell niche

European Journal of Cell Biology
Laura Cristina CeafalanEugen Radu

Abstract

Adult tissue homeostasis and repair relies on prompt and appropriate intervention by tissue-specific adult stem cells (SCs). SCs have the ability to self-renew; upon appropriate stimulation, they proliferate and give rise to specialized cells. An array of environmental signals is important for maintenance of the SC pool and SC survival, behavior, and fate. Within this special microenvironment, commonly known as the stem cell niche (SCN), SC behavior and fate are regulated by soluble molecules and direct molecular contacts via adhesion molecules providing connections to local supporting cells and the extracellular matrix. Besides the extensively discussed array of soluble molecules, the expression of adhesion molecules and molecular contacts is another fundamental mechanism regulating niche occupancy and SC mobilization upon activation. Some adhesion molecules are differentially expressed and have tissue-specific consequences, likely reflecting the structural differences in niche composition and design, especially the presence or absence of a stromal counterpart. However, the distribution and identity of intercellular molecular contacts for adhesion and adhesion-mediated signaling within stromal and non-stromal SCN have not been...Continue Reading

Citations

Nov 21, 2019·Open Biology·María Lobo-PecellínAcaimo González-Reyes
Jul 31, 2020·PloS One·Najme KhorasaniAbbas Nowzari-Dalini
Aug 6, 2020·Frontiers in Cell and Developmental Biology·Anastasiia D KurenkovaAndrei S Chagin
Sep 28, 2021·The Journal of Cell Biology·Thomas BessyManuel Théry

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