Heterochromatic genes in Drosophila: a comparative analysis of two genes.

Genetics
Sandra R SchulzeB M Honda

Abstract

Centromeric heterochromatin comprises approximately 30% of the Drosophila melanogaster genome, forming a transcriptionally repressive environment that silences euchromatic genes juxtaposed nearby. Surprisingly, there are genes naturally resident in heterochromatin, which appear to require this environment for optimal activity. Here we report an evolutionary analysis of two genes, Dbp80 and RpL15, which are adjacent in proximal 3L heterochromatin of D. melanogaster. DmDbp80 is typical of previously described heterochromatic genes: large, with repetitive sequences in its many introns. In contrast, DmRpL15 is uncharacteristically small. The orthologs of these genes were examined in D. pseudoobscura and D. virilis. In situ hybridization and whole-genome assembly analysis show that these genes are adjacent, but not centromeric in the genome of D. pseudoobscura, while they are located on different chromosomal elements in D. virilis. Dbp80 gene organization differs dramatically among these species, while RpL15 structure is conserved. A bioinformatic analysis in five additional Drosophila species demonstrates active repositioning of these genes both within and between chromosomal elements. This study shows that Dbp80 and RpL15 can func...Continue Reading

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Citations

Oct 9, 2008·Current Opinion in Genetics & Development·Stephen Brown, Martin P Zeidler
Nov 19, 2014·PloS One·Roberta MoschettiPatrizio Dimitri
May 22, 2020·Evolution; International Journal of Organic Evolution·Carl E HjelmenJohn Spencer Johnston
Jul 20, 2019·Trends in Genetics : TIG·René M MarsanoPatrizio Dimitri

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